DegronMD

Uniprot ID: P61599

Source protein: N-alpha-acetyltransferase 20

Source gene: NAA20

Class: DEG_Kelch_Keap1_1

Location: 139:144

E3 ligase: KEAP1

DEGRON score: 0.9544

ASA_SCORE: 77.3667

COIL: 0.8327

CONS_SCORE: 0.2187

DSS_SCORE: 0.3079

HELIX: 0.0248

FCONS_SCORE: 0.3596

RIG_SCORE: 0.6851

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A149T	TCGA-2W-A8YY	CESC	TCGA	SASNGE	DEG_Kelch_Keap1_1	0.1944
p.A149T	DO223732	CESC	ICGC	SASNGE	DEG_Kelch_Keap1_1	0.1944
p.R132K	TCGA-AP-A059	UCEC	TCGA	SASNGE	DEG_Kelch_Keap1_1	0.1389
p.R132K	DO41361	UCEC	ICGC	SASNGE	DEG_Kelch_Keap1_1	0.1389
p.Y150C	TCGA-CN-6997	HNSC	TCGA	SASNGE	DEG_Kelch_Keap1_1	0.1667
p.Y150C	DO14414	HNSC	ICGC	SASNGE	DEG_Kelch_Keap1_1	0.1667
p.D151N	TCGA-EJ-5519	PRAD	TCGA	SASNGE	DEG_Kelch_Keap1_1	0.1389
p.D151N	DO36247	PRAD	ICGC	SASNGE	DEG_Kelch_Keap1_1	0.1389
p.E144D	DO229022	LICA	ICGC	SASNGE	DEG_Kelch_Keap1_1	0.6758
p.Y137C	SIDM00082	Melanoma	GDSC	SASNGE	DEG_Kelch_Keap1_1	0.7222
p.Y137C	ACH-001190	Skin Cancer	CCLE	SASNGE	DEG_Kelch_Keap1_1	0.7222
p.Y137C	SK-MEL-2	skin	COSMIC	SASNGE	DEG_Kelch_Keap1_1	0.7222
p.Y137H	SIDM00789	Colorectal Carcinoma	GDSC	SASNGE	DEG_Kelch_Keap1_1	0.7222
p.Y137H	ACH-000997	Colon/Colorectal Cancer	CCLE	SASNGE	DEG_Kelch_Keap1_1	0.7222
p.Y137H	HCT-15	large_intestine	COSMIC	SASNGE	DEG_Kelch_Keap1_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P61599	N-alpha-acetyltransferase 20	DEG_Kelch_Keap1_1	139:144	SASNGE	KEAP1	0.9544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons