DegronMD - P61764(STXBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P79A	TCGA-44-2656	LUAD	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.1389
p.P79A	DO26052	LUAD	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.1389
p.E72Q	TCGA-97-8174	LUAD	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.5633
p.E72Q	DO25199	LUAD	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.5633
p.E81D	TCGA-AA-A00N	COAD	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.0833
p.E81D	DO9876	COAD	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.0833
p.R64C	TCGA-B5-A11E	UCEC	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.719
p.R64C	DO41644	UCEC	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.719
p.T56M	TCGA-BR-8361	STAD	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.1111
p.T56M	DO48032	STAD	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.1111
p.L76V	TCGA-E5-A4TZ	BLCA	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.2222
p.L76V	TCGA-KQ-A41N	BLCA	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.2222
p.L76V	DO44055	BLCA	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.2222
p.L76V	DO223588	BLCA	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.2222
p.V74A	TCGA-G3-AAV3	LIHC	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.2778
p.V74A	DO52297	LIHC	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.2778
p.R64H	DO227987	COCA	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.7133
p.T56S	DO228313	LICA	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.1111
p.L68I	SIDM00193	Colorectal Carcinoma	GDSC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.7174
p.L68I	ACH-000991	Colon/Colorectal Cancer	CCLE	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.7174
p.L68I	SNU-81	large intestine	COSMIC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.7174
p.L54I	SNU-81	large intestine	COSMIC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation rewiring degron network	0.0556
p.S72Y	LNCaP-Clone-FGC	prostate	COSMIC	RREPLPSLE	DEG_APCC_DBOX_1	64:72	Mutation altering degron motif	0.712

Kaplan plot for STXBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STXBP1

UniProt ID: P61764

Entrez ID: 6812

Protein name: Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STXBP1 in