DegronMD

Uniprot ID: P61764

Source protein: Syntaxin-binding protein 1

Source gene: STXBP1

Class: DEG_APCC_DBOX_1

Location: 64:72

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8727

ASA_SCORE: 85.1

COIL: 0.9366

CONS_SCORE: 0.5532

DSS_SCORE: 0.269

HELIX: 0.0226

FCONS_SCORE: 0.8956

RIG_SCORE: 0.7918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P79A	TCGA-44-2656	LUAD	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	0.1389
p.P79A	DO26052	LUAD	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	0.1389
p.E72Q	TCGA-97-8174	LUAD	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	0.5633
p.E72Q	DO25199	LUAD	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	0.5633
p.E81D	TCGA-AA-A00N	COAD	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	0.0833
p.E81D	DO9876	COAD	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	0.0833
p.R64C	TCGA-B5-A11E	UCEC	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	0.719
p.R64C	DO41644	UCEC	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	0.719
p.T56M	TCGA-BR-8361	STAD	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	0.1111
p.T56M	DO48032	STAD	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	0.1111
p.L76V	TCGA-E5-A4TZ	BLCA	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	0.2222
p.L76V	TCGA-KQ-A41N	BLCA	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	0.2222
p.L76V	DO44055	BLCA	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	0.2222
p.L76V	DO223588	BLCA	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	0.2222
p.V74A	TCGA-G3-AAV3	LIHC	TCGA	RREPLPSLE	DEG_APCC_DBOX_1	0.2778
p.V74A	DO52297	LIHC	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	0.2778
p.R64H	DO227987	COCA	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	0.7133
p.T56S	DO228313	LICA	ICGC	RREPLPSLE	DEG_APCC_DBOX_1	0.1111
p.L68I	SIDM00193	Colorectal Carcinoma	GDSC	RREPLPSLE	DEG_APCC_DBOX_1	0.7174
p.L68I	ACH-000991	Colon/Colorectal Cancer	CCLE	RREPLPSLE	DEG_APCC_DBOX_1	0.7174
p.L68I	SNU-81	large_intestine	COSMIC	RREPLPSLE	DEG_APCC_DBOX_1	0.7174
p.L54I	SNU-81	large_intestine	COSMIC	RREPLPSLE	DEG_APCC_DBOX_1	0.0556
p.S72Y	LNCaP-Clone-FGC	prostate	COSMIC	RREPLPSLE	DEG_APCC_DBOX_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P61764	Syntaxin-binding protein 1	DEG_APCC_DBOX_1	64:72	RREPLPSLE	APC,CDC20,FZR1	0.8727	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons