DegronMD - P61923(COPZ1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R177P	TCGA-04-1648	OV	TCGA	LLR	DEG_APCC_TPR_1	175:177	Mutation altering degron motif	0.7512
p.A167V	TCGA-AM-5821	COAD	TCGA	LLR	DEG_APCC_TPR_1	175:177	Mutation rewiring degron network	0.1111
p.K172E	TCGA-CN-6010	HNSC	TCGA	LLR	DEG_APCC_TPR_1	175:177	Mutation blocking ubiquitination signal	0.6944
p.E169K	TCGA-CV-7418	HNSC	TCGA	LLR	DEG_APCC_TPR_1	175:177	Mutation rewiring degron network	0.1667
p.I171M	TCGA-EO-A3AS	UCEC	TCGA	LLR	DEG_APCC_TPR_1	175:177	Mutation rewiring degron network	0.2222
p.A175T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LLR	DEG_APCC_TPR_1	175:177	Mutation altering degron motif	0.7139
p.A175T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LLR	DEG_APCC_TPR_1	175:177	Mutation altering degron motif	0.7139
p.A175T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LLR	DEG_APCC_TPR_1	175:177	Mutation altering degron motif	0.7139
p.A167T	ACH-000995	Leukemia	CCLE	LLR	DEG_APCC_TPR_1	175:177	Mutation rewiring degron network	0.1111
p.A167T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LLR	DEG_APCC_TPR_1	175:177	Mutation rewiring degron network	0.1111
p.W173S	ACH-001852	Bile Duct Cancer	CCLE	LLR	DEG_APCC_TPR_1	175:177	Mutation rewiring degron network	0.2778
p.L176F	Mewo	skin	COSMIC	LLR	DEG_APCC_TPR_1	175:177	Mutation altering degron motif	0.6981

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons