DegronMD

Uniprot ID: P61923

Source protein: Coatomer subunit zeta-1

Source gene: COPZ1

Class: DEG_APCC_TPR_1

Location: 175:177

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7029

ASA_SCORE: 117.6333

COIL: 0.6623

CONS_SCORE: 0.6201

DSS_SCORE: 0.7297

HELIX: 0.352

FCONS_SCORE: 1.0398

RIG_SCORE: 0.8372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R177P	TCGA-04-1648	OV	TCGA	LLR	DEG_APCC_TPR_1	0.7512
p.A167V	TCGA-AM-5821	COAD	TCGA	LLR	DEG_APCC_TPR_1	0.1111
p.K172E	TCGA-CN-6010	HNSC	TCGA	LLR	DEG_APCC_TPR_1	0.6944
p.E169K	TCGA-CV-7418	HNSC	TCGA	LLR	DEG_APCC_TPR_1	0.1667
p.I171M	TCGA-EO-A3AS	UCEC	TCGA	LLR	DEG_APCC_TPR_1	0.2222
p.A175T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LLR	DEG_APCC_TPR_1	0.7139
p.A175T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LLR	DEG_APCC_TPR_1	0.7139
p.A175T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LLR	DEG_APCC_TPR_1	0.7139
p.A167T	ACH-000995	Leukemia	CCLE	LLR	DEG_APCC_TPR_1	0.1111
p.A167T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LLR	DEG_APCC_TPR_1	0.1111
p.W173S	ACH-001852	Bile Duct Cancer	CCLE	LLR	DEG_APCC_TPR_1	0.2778
p.L176F	Mewo	skin	COSMIC	LLR	DEG_APCC_TPR_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P61923	Coatomer subunit zeta-1	DEG_APCC_TPR_1	175:177	LLR	APC,CDC20,FZR1	0.7029	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons