DegronMD - P62140(PPP1CB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R319Q	TCGA-DK-A6AW	BLCA	TCGA	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation altering degron motif	0.6218
p.R319Q	DO48566	BLCA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation altering degron motif	0.6218
p.R313H	TCGA-EC-A24G	UCEC	TCGA	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation rewiring degron network	0.3056
p.R313H	DO40996	UCEC	ICGC	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation rewiring degron network	0.3056
p.P324Q	TCGA-EE-A20F	SKCM	TCGA	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation rewiring degron network	0.2222
p.P324Q	DO37961	SKCM	ICGC	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation rewiring degron network	0.2222
p.P318H	DO233207	GACA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation altering degron motif	0.6583
p.R313L	DO229027	LICA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation rewiring degron network	0.3056
p.R313L	DO229009	LICA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation rewiring degron network	0.3056
p.G307C	DO32976	PACA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation rewiring degron network	0.1389
p.G307V	DO32976	PACA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation rewiring degron network	0.1389
p.Y306H	DO51474	PACA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation blocking phosphorylation signal	0.5556
p.S311F	SIDM01106	Melanoma	GDSC	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation blocking phosphorylation signal	0.6944
p.S311F	ACH-000822	Skin Cancer	CCLE	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation blocking phosphorylation signal	0.6944
p.S311F	SK-MEL-24	skin	COSMIC	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation blocking phosphorylation signal	0.6944
p.G308R	ACH-000261	Lung Cancer	CCLE	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation rewiring degron network	0.1667
p.G308R	ACH-002122	Lung Cancer	CCLE	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation rewiring degron network	0.1667
p.T316I	ACH-001270	Sarcoma	CCLE	PVTPPRT	DEG_SCF_FBW7_1	314:320	Mutation altering degron motif	0.8189

Kaplan plot for PPP1CB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1CB

UniProt ID: P62140

Entrez ID: 5500

Protein name: Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP1CB in