DegronMD

Uniprot ID: P62140

Source protein: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Source gene: PPP1CB

Class: DEG_SCF_FBW7_1

Location: 314:320

E3 ligase: FBXW7

DEGRON score: 0.6819

ASA_SCORE: 101.5714

COIL: 0.956

CONS_SCORE: 0.2843

DSS_SCORE: 0.7926

HELIX: 0.0119

FCONS_SCORE: 1.0766

RIG_SCORE: 0.6244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R319Q	TCGA-DK-A6AW	BLCA	TCGA	PVTPPRT	DEG_SCF_FBW7_1	0.6218
p.R319Q	DO48566	BLCA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	0.6218
p.R313H	TCGA-EC-A24G	UCEC	TCGA	PVTPPRT	DEG_SCF_FBW7_1	0.3056
p.R313H	DO40996	UCEC	ICGC	PVTPPRT	DEG_SCF_FBW7_1	0.3056
p.P324Q	TCGA-EE-A20F	SKCM	TCGA	PVTPPRT	DEG_SCF_FBW7_1	0.2222
p.P324Q	DO37961	SKCM	ICGC	PVTPPRT	DEG_SCF_FBW7_1	0.2222
p.P318H	DO233207	GACA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	0.6583
p.R313L	DO229027	LICA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	0.3056
p.R313L	DO229009	LICA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	0.3056
p.G307C	DO32976	PACA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	0.1389
p.G307V	DO32976	PACA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	0.1389
p.Y306H	DO51474	PACA	ICGC	PVTPPRT	DEG_SCF_FBW7_1	0.5556
p.S311F	SIDM01106	Melanoma	GDSC	PVTPPRT	DEG_SCF_FBW7_1	0.6944
p.S311F	ACH-000822	Skin Cancer	CCLE	PVTPPRT	DEG_SCF_FBW7_1	0.6944
p.S311F	SK-MEL-24	skin	COSMIC	PVTPPRT	DEG_SCF_FBW7_1	0.6944
p.G308R	ACH-000261	Lung Cancer	CCLE	PVTPPRT	DEG_SCF_FBW7_1	0.1667
p.G308R	ACH-002122	Lung Cancer	CCLE	PVTPPRT	DEG_SCF_FBW7_1	0.1667
p.T316I	ACH-001270	Sarcoma	CCLE	PVTPPRT	DEG_SCF_FBW7_1	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P62140	Serine/threonine-protein phosphatase PP1-beta catalytic subunit	DEG_SCF_FBW7_1	314:320	PVTPPRT	FBXW7	0.6819	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons