DegronMD - P62753(RPS6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q248H	TCGA-18-3406	LUSC	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.0556
p.Q248H	DO26438	LUSC	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.0556
p.A220S	TCGA-29-1691	OV	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.0556
p.A220S	DO32133	OV	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.0556
p.A229V	TCGA-AA-3811	COAD	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.3056
p.A229V	DO7962	COAD	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.3056
p.A229V	SIDM00202	Ewing's Sarcoma	GDSC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.3056
p.A229V	ACH-002118	Bone Cancer	CCLE	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.3056
p.A229V	EW-3	bone	COSMIC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.3056
p.R232H	TCGA-AP-A0LE	UCEC	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.7133
p.R232H	TCGA-XK-AAIW	PRAD	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.7133
p.R232H	DO51407	PRAD	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.7133
p.R232H	DO43418	UCEC	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.7133
p.K230N	TCGA-BT-A20J	BLCA	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.5806
p.K230N	DO457	BLCA	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.5806
p.R233I	TCGA-D1-A17Q	UCEC	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.6991
p.R233I	DO41903	UCEC	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.6991
p.R232C	TCGA-EO-A22R	UCEC	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.719
p.R232C	DO42713	UCEC	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.719
p.R224H	TCGA-EO-A22X	UCEC	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1667
p.R224H	DO43907	UCEC	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1667
p.R224H	SIDM01611	Endometrial Carcinoma	GDSC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1667
p.R224H	ACH-000996	Endometrial/Uterine Cancer	CCLE	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1667
p.E222D	TCGA-G2-A2EO	BLCA	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1111
p.E222D	DO456	BLCA	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1111
p.S236C	TCGA-OL-A5RW	BRCA	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.7541
p.S236C	DO44238	BRCA	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.7541
p.A229S	DO472	BLCA	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.3056
p.S242F	SIDM01300	Colorectal Carcinoma	GDSC	KRRRLSSLR	DEG_APCC_DBOX_1	230:238	Mutation blocking phosphorylation signal	0.6667

Kaplan plot for RPS6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPS6

UniProt ID: P62753

Entrez ID: 6194

Protein name: 40S ribosomal protein S6 (Phosphoprotein NP33) (Small ribosomal subunit protein eS6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RPS6 in