DegronMD

Uniprot ID: P62753

Source protein: 40S ribosomal protein S6

Source gene: RPS6

Class: DEG_APCC_DBOX_1

Location: 230:238

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9518

ASA_SCORE: 131.3222

COIL: 0.4243

CONS_SCORE: 0.3816

DSS_SCORE: 0.6133

HELIX: 0.5694

FCONS_SCORE: 1.1338

RIG_SCORE: 0.7007

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q248H	TCGA-18-3406	LUSC	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	0.0556
p.Q248H	DO26438	LUSC	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.0556
p.A220S	TCGA-29-1691	OV	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	0.0556
p.A220S	DO32133	OV	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.0556
p.A229V	TCGA-AA-3811	COAD	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	0.3056
p.A229V	DO7962	COAD	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.3056
p.A229V	SIDM00202	Ewing's Sarcoma	GDSC	KRRRLSSLR	DEG_APCC_DBOX_1	0.3056
p.A229V	ACH-002118	Bone Cancer	CCLE	KRRRLSSLR	DEG_APCC_DBOX_1	0.3056
p.A229V	EW-3	bone	COSMIC	KRRRLSSLR	DEG_APCC_DBOX_1	0.3056
p.R232H	TCGA-AP-A0LE	UCEC	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	0.7133
p.R232H	TCGA-XK-AAIW	PRAD	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	0.7133
p.R232H	DO51407	PRAD	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.7133
p.R232H	DO43418	UCEC	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.7133
p.K230N	TCGA-BT-A20J	BLCA	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	0.5806
p.K230N	DO457	BLCA	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.5806
p.R233I	TCGA-D1-A17Q	UCEC	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	0.6991
p.R233I	DO41903	UCEC	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.6991
p.R232C	TCGA-EO-A22R	UCEC	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	0.719
p.R232C	DO42713	UCEC	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.719
p.R224H	TCGA-EO-A22X	UCEC	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	0.1667
p.R224H	DO43907	UCEC	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.1667
p.R224H	SIDM01611	Endometrial Carcinoma	GDSC	KRRRLSSLR	DEG_APCC_DBOX_1	0.1667
p.R224H	ACH-000996	Endometrial/Uterine Cancer	CCLE	KRRRLSSLR	DEG_APCC_DBOX_1	0.1667
p.E222D	TCGA-G2-A2EO	BLCA	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	0.1111
p.E222D	DO456	BLCA	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.1111
p.S236C	TCGA-OL-A5RW	BRCA	TCGA	KRRRLSSLR	DEG_APCC_DBOX_1	0.7541
p.S236C	DO44238	BRCA	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.7541
p.A229S	DO472	BLCA	ICGC	KRRRLSSLR	DEG_APCC_DBOX_1	0.3056
p.S242F	SIDM01300	Colorectal Carcinoma	GDSC	KRRRLSSLR	DEG_APCC_DBOX_1	0.6667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRRRLSSLR

Degron related mutations and impact score

Drug responses associated with RPS6 mutations

All proteins holding degron of KRRRLSSLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P62753	40S ribosomal protein S6	DEG_APCC_DBOX_1	230:238	KRRRLSSLR	APC,CDC20,FZR1	0.9518	More...