DegronMD - P63010(AP2B1)

FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L615P	TCGA-AA-3492	COAD	TCGA	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2222
p.L615P	DO8224	COAD	ICGC	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2222
p.T613M	TCGA-CM-6171	COAD	TCGA	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2778
p.T613M	DO8151	COAD	ICGC	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2778
p.Q619K	TCGA-DS-A1OC	CESC	TCGA	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1111
p.Q619K	DO6329	CESC	ICGC	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1111
p.G598R	TCGA-VP-A87E	PRAD	TCGA	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0833
p.G598R	DO51387	PRAD	ICGC	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0833
p.G598E	TCGA-VP-A87E	PRAD	TCGA	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0833
p.G598E	DO51387	PRAD	ICGC	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0833
p.A612T	TCGA-ZF-AA53	BLCA	TCGA	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.3056
p.A612T	DO219096	BLCA	ICGC	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.3056
p.N614S	ACH-001147	Lymphoma	CCLE	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.Q611H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VGTTT	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AP2B1

UniProt ID: P63010

Entrez ID: 163

Protein name: AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AP2B1 in