DegronMD

Uniprot ID: P63010

Source protein: AP-2 complex subunit beta

Source gene: AP2B1

Class: DEG_SPOP_SBC_1

Location: 607:611

E3 ligase: SPOP

DEGRON score: 0.9877

ASA_SCORE: 72.8

COIL: 0.8662

CONS_SCORE: 0.2623

DSS_SCORE: 0.6813

HELIX: 0.088

FCONS_SCORE: 0.9948

RIG_SCORE: 0.6604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L615P	TCGA-AA-3492	COAD	TCGA	VGTTT	DEG_SPOP_SBC_1	0.2222
p.L615P	DO8224	COAD	ICGC	VGTTT	DEG_SPOP_SBC_1	0.2222
p.T613M	TCGA-CM-6171	COAD	TCGA	VGTTT	DEG_SPOP_SBC_1	0.2778
p.T613M	DO8151	COAD	ICGC	VGTTT	DEG_SPOP_SBC_1	0.2778
p.Q619K	TCGA-DS-A1OC	CESC	TCGA	VGTTT	DEG_SPOP_SBC_1	0.1111
p.Q619K	DO6329	CESC	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1111
p.G598R	TCGA-VP-A87E	PRAD	TCGA	VGTTT	DEG_SPOP_SBC_1	0.0833
p.G598R	DO51387	PRAD	ICGC	VGTTT	DEG_SPOP_SBC_1	0.0833
p.G598E	TCGA-VP-A87E	PRAD	TCGA	VGTTT	DEG_SPOP_SBC_1	0.0833
p.G598E	DO51387	PRAD	ICGC	VGTTT	DEG_SPOP_SBC_1	0.0833
p.A612T	TCGA-ZF-AA53	BLCA	TCGA	VGTTT	DEG_SPOP_SBC_1	0.3056
p.A612T	DO219096	BLCA	ICGC	VGTTT	DEG_SPOP_SBC_1	0.3056
p.N614S	ACH-001147	Lymphoma	CCLE	VGTTT	DEG_SPOP_SBC_1	0.25
p.Q611H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VGTTT	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P63010	AP-2 complex subunit beta	DEG_SPOP_SBC_1	607:611	VGTTT	SPOP	0.9877	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7125:7129	VGTTT	SPOP	0.9976	More...
Q86T24	Transcriptional regulator Kaiso	DEG_SPOP_SBC_1	627:631	VGTTT	SPOP	0.6009	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6597:6601	VGTTT	SPOP	0.9955	More...
Q92733	Proline-rich protein PRCC	DEG_SPOP_SBC_1	233:237	VGTTT	SPOP	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons