DegronMD

Uniprot ID: Q86T24

Source protein: Transcriptional regulator Kaiso

Source gene: ZBTB33

Class: DEG_SPOP_SBC_1

Location: 627:631

E3 ligase: SPOP

DEGRON score: 0.6009

ASA_SCORE: 62.96

COIL: 0.834

CONS_SCORE: 0.5276

DSS_SCORE: 0.6596

HELIX: 0.037

FCONS_SCORE: 1.0389

RIG_SCORE: 0.6786

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P626S	TCGA-BF-A3DL	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	0.3056
p.P626S	DO51238	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	0.3056
p.M638I	TCGA-BG-A0VX	UCEC	TCGA	VGTTT	DEG_SPOP_SBC_1	0.1389
p.M638I	DO43923	UCEC	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1389
p.G628R	TCGA-CV-7248	HNSC	TCGA	VGTTT	DEG_SPOP_SBC_1	0.6457
p.G628R	DO14806	HNSC	ICGC	VGTTT	DEG_SPOP_SBC_1	0.6457
p.W640C	TCGA-E6-A1LX	UCEC	TCGA	VGTTT	DEG_SPOP_SBC_1	0.0833
p.W640C	DO41020	UCEC	ICGC	VGTTT	DEG_SPOP_SBC_1	0.0833
p.G628E	TCGA-EE-A3AF	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	0.6087
p.G628E	DO37911	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	0.6087
p.G628W	TCGA-FS-A1ZP	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	0.6714
p.G628W	DO37703	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	0.6714
p.S632F	DO50320	ESAD	ICGC	VGTTT	DEG_SPOP_SBC_1	0.3056
p.P626T	DO228155	LIAD	ICGC	VGTTT	DEG_SPOP_SBC_1	0.3056
p.P625T	SIDM00773	Non-Cancerous	GDSC	VGTTT	DEG_SPOP_SBC_1	0.2778
p.P625T	SIDM00855	Other Sarcomas	GDSC	VGTTT	DEG_SPOP_SBC_1	0.2778
p.P625T	SIDM01133	Other Solid Cancers	GDSC	VGTTT	DEG_SPOP_SBC_1	0.2778
p.P625T	SIDM00720	Mesothelioma	GDSC	VGTTT	DEG_SPOP_SBC_1	0.2778
p.P625T	SIDM01749	Osteosarcoma	GDSC	VGTTT	DEG_SPOP_SBC_1	0.2778
p.P625T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VGTTT	DEG_SPOP_SBC_1	0.2778
p.P625L	SIDM00290	Gastric Carcinoma	GDSC	VGTTT	DEG_SPOP_SBC_1	0.2778
p.P625L	ACH-000847	Gastric Cancer	CCLE	VGTTT	DEG_SPOP_SBC_1	0.2778
p.P625L	HGC-27	stomach	COSMIC	VGTTT	DEG_SPOP_SBC_1	0.2778
p.D620N	SIDM00679	Cervical Carcinoma	GDSC	VGTTT	DEG_SPOP_SBC_1	0.1389
p.D620N	ACH-001525	Cervical Cancer	CCLE	VGTTT	DEG_SPOP_SBC_1	0.1389
p.D620N	HT-3	cervix	COSMIC	VGTTT	DEG_SPOP_SBC_1	0.1389
p.N635S	ACH-001335	Cervical Cancer	CCLE	VGTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P63010	AP-2 complex subunit beta	DEG_SPOP_SBC_1	607:611	VGTTT	SPOP	0.9877	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7125:7129	VGTTT	SPOP	0.9976	More...
Q86T24	Transcriptional regulator Kaiso	DEG_SPOP_SBC_1	627:631	VGTTT	SPOP	0.6009	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6597:6601	VGTTT	SPOP	0.9955	More...
Q92733	Proline-rich protein PRCC	DEG_SPOP_SBC_1	233:237	VGTTT	SPOP	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGTTT

Degron related mutations and impact score

Drug responses associated with ZBTB33 mutations

All proteins holding degron of VGTTT