DegronMD - Q92733(PRCC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P231S	TCGA-BF-A1PZ	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2778
p.P231S	DO50279	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2778
p.S227F	TCGA-CQ-7063	HNSC	TCGA	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1667
p.S227F	DO14702	HNSC	ICGC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1667
p.T238I	TCGA-DA-A95X	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation blocking phosphorylation signal	0.75
p.T238I	DO219480	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation blocking phosphorylation signal	0.75
p.I245V	TCGA-DK-A2I6	BLCA	TCGA	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1111
p.I245V	DO798	BLCA	ICGC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1111
p.I245M	TCGA-FD-A6TC	BLCA	TCGA	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1111
p.I245M	DO49755	BLCA	ICGC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1111
p.S243C	TCGA-GU-AATP	BLCA	TCGA	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation blocking phosphorylation signal	0.6111
p.S243C	DO51894	BLCA	ICGC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation blocking phosphorylation signal	0.6111
p.L229F	SIDM00466	Ovarian Carcinoma	GDSC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2222
p.L229F	SIDM00018	Acute Myeloid Leukemia	GDSC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2222
p.L229F	SIDM01444	Glioblastoma	GDSC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2222
p.L229F	KO52	haematopoietic and lymphoid tissue	COSMIC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2222
p.L229F	OVKATE	ovary	COSMIC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2222
p.P231L	SIDM01757	Bladder Carcinoma	GDSC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2778
p.P231L	ACH-000741	Bladder Cancer	CCLE	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2778
p.S228C	SIDM01776	Plasma Cell Myeloma	GDSC	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1944
p.S228C	ACH-001162	Myeloma	CCLE	VGTTT	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1944

Kaplan plot for PRCC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRCC

UniProt ID: Q92733

Entrez ID: 5546

Protein name: Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRCC in