DegronMD

Uniprot ID: Q92733

Source protein: Proline-rich protein PRCC

Source gene: PRCC

Class: DEG_SPOP_SBC_1

Location: 233:237

E3 ligase: SPOP

DEGRON score: 0.9958

ASA_SCORE: 84.74

COIL: 0.9486

CONS_SCORE: 0.2977

DSS_SCORE: 0.5592

HELIX: 0.016

FCONS_SCORE: 0.8457

RIG_SCORE: 0.6767

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P231S	TCGA-BF-A1PZ	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	0.2778
p.P231S	DO50279	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	0.2778
p.S227F	TCGA-CQ-7063	HNSC	TCGA	VGTTT	DEG_SPOP_SBC_1	0.1667
p.S227F	DO14702	HNSC	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1667
p.T238I	TCGA-DA-A95X	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	0.75
p.T238I	DO219480	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	0.75
p.I245V	TCGA-DK-A2I6	BLCA	TCGA	VGTTT	DEG_SPOP_SBC_1	0.1111
p.I245V	DO798	BLCA	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1111
p.I245M	TCGA-FD-A6TC	BLCA	TCGA	VGTTT	DEG_SPOP_SBC_1	0.1111
p.I245M	DO49755	BLCA	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1111
p.S243C	TCGA-GU-AATP	BLCA	TCGA	VGTTT	DEG_SPOP_SBC_1	0.6111
p.S243C	DO51894	BLCA	ICGC	VGTTT	DEG_SPOP_SBC_1	0.6111
p.L229F	SIDM00466	Ovarian Carcinoma	GDSC	VGTTT	DEG_SPOP_SBC_1	0.2222
p.L229F	SIDM00018	Acute Myeloid Leukemia	GDSC	VGTTT	DEG_SPOP_SBC_1	0.2222
p.L229F	SIDM01444	Glioblastoma	GDSC	VGTTT	DEG_SPOP_SBC_1	0.2222
p.L229F	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	VGTTT	DEG_SPOP_SBC_1	0.2222
p.L229F	OVKATE	ovary	COSMIC	VGTTT	DEG_SPOP_SBC_1	0.2222
p.P231L	SIDM01757	Bladder Carcinoma	GDSC	VGTTT	DEG_SPOP_SBC_1	0.2778
p.P231L	ACH-000741	Bladder Cancer	CCLE	VGTTT	DEG_SPOP_SBC_1	0.2778
p.S228C	SIDM01776	Plasma Cell Myeloma	GDSC	VGTTT	DEG_SPOP_SBC_1	0.1944
p.S228C	ACH-001162	Myeloma	CCLE	VGTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P63010	AP-2 complex subunit beta	DEG_SPOP_SBC_1	607:611	VGTTT	SPOP	0.9877	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7125:7129	VGTTT	SPOP	0.9976	More...
Q86T24	Transcriptional regulator Kaiso	DEG_SPOP_SBC_1	627:631	VGTTT	SPOP	0.6009	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6597:6601	VGTTT	SPOP	0.9955	More...
Q92733	Proline-rich protein PRCC	DEG_SPOP_SBC_1	233:237	VGTTT	SPOP	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons