DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 6597:6601

E3 ligase: SPOP

DEGRON score: 0.9955

ASA_SCORE: 79.28

COIL: 0.7668

CONS_SCORE: 0

DSS_SCORE: 0.4954

HELIX: 0.0126

FCONS_SCORE: 0

RIG_SCORE: 0.7047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N6596H	TCGA-A5-A0G2	UCEC	TCGA	VGTTT	DEG_SPOP_SBC_1	0.3056
p.N6596H	DO41235	UCEC	ICGC	VGTTT	DEG_SPOP_SBC_1	0.3056
p.T6601A	TCGA-AA-3845	COAD	TCGA	VGTTT	DEG_SPOP_SBC_1	0.7139
p.T6601A	DO10020	COAD	ICGC	VGTTT	DEG_SPOP_SBC_1	0.7139
p.P6588H	TCGA-AZ-4315	COAD	TCGA	VGTTT	DEG_SPOP_SBC_1	0.0833
p.P6588H	DO8842	COAD	ICGC	VGTTT	DEG_SPOP_SBC_1	0.0833
p.S6608L	TCGA-BH-A0AW	BRCA	TCGA	VGTTT	DEG_SPOP_SBC_1	0.1389
p.S6608L	TCGA-FW-A3R5	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	0.1389
p.S6608L	TCGA-QB-A6FS	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	0.1389
p.S6608L	TCGA-X8-AAAR	ESCA	TCGA	VGTTT	DEG_SPOP_SBC_1	0.1389
p.S6608L	DO5005	BRCA	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1389
p.S6608L	DO233665	GACA	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1389
p.S6608L	DO222662	MELA	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1389
p.S6608L	DO37406	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1389
p.S6608L	DO48654	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1389
p.S6589F	TCGA-D3-A8GI	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	0.1111
p.S6589F	DO218840	SKCA	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1111
p.S6589F	DO50284	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	0.1111
p.E6605K	TCGA-EB-A431	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	0.2222
p.E6605K	DO37671	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	0.2222
p.T6600I	TCGA-EE-A2MR	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	0.7078
p.T6600I	DO37819	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	0.7078
p.Y6587C	DO230334	COCA	ICGC	VGTTT	DEG_SPOP_SBC_1	0.0556
p.S6602Y	DO233166	GACA	ICGC	VGTTT	DEG_SPOP_SBC_1	0.3056
p.T6590P	DO44854	LICA	ICGC	VGTTT	DEG_SPOP_SBC_1	0.5833
p.K6604T	SIDM00254	Neuroblastoma	GDSC	VGTTT	DEG_SPOP_SBC_1	0.3611
p.K6604T	SIDM00720	Mesothelioma	GDSC	VGTTT	DEG_SPOP_SBC_1	0.3611
p.S6602P	ACH-001645	Skin Cancer	CCLE	VGTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P63010	AP-2 complex subunit beta	DEG_SPOP_SBC_1	607:611	VGTTT	SPOP	0.9877	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7125:7129	VGTTT	SPOP	0.9976	More...
Q86T24	Transcriptional regulator Kaiso	DEG_SPOP_SBC_1	627:631	VGTTT	SPOP	0.6009	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6597:6601	VGTTT	SPOP	0.9955	More...
Q92733	Proline-rich protein PRCC	DEG_SPOP_SBC_1	233:237	VGTTT	SPOP	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGTTT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VGTTT