DegronMD - Q86T24(ZBTB33)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T290K	TCGA-49-AARO	LUAD	TCGA	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.7306
p.T290K	DO218924	LUAD	ICGC	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.7306
p.P291Q	TCGA-55-A494	LUAD	TCGA	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.3056
p.P291Q	DO23794	LUAD	ICGC	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.3056
p.P278T	TCGA-B5-A0K8	UCEC	TCGA	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1944
p.P278T	DO40831	UCEC	ICGC	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.1944
p.P626S	TCGA-BF-A3DL	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.3056
p.P626S	DO51238	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.3056
p.M638I	TCGA-BG-A0VX	UCEC	TCGA	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.1389
p.M638I	DO43923	UCEC	ICGC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.1389
p.G628R	TCGA-CV-7248	HNSC	TCGA	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation altering degron motif	0.6457
p.G628R	DO14806	HNSC	ICGC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation altering degron motif	0.6457
p.W640C	TCGA-E6-A1LX	UCEC	TCGA	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.0833
p.W640C	DO41020	UCEC	ICGC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.0833
p.G628E	TCGA-EE-A3AF	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation altering degron motif	0.6087
p.G628E	DO37911	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation altering degron motif	0.6087
p.G628W	TCGA-FS-A1ZP	SKCM	TCGA	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation altering degron motif	0.6714
p.G628W	DO37703	SKCM	ICGC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation altering degron motif	0.6714
p.T290A	TCGA-QL-A97D	COAD	TCGA	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.7139
p.T290A	DO51732	COAD	ICGC	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.7139
p.S632F	DO50320	ESAD	ICGC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.3056
p.P626T	DO228155	LIAD	ICGC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.3056
p.V294A	DO232761	PBCA	ICGC	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation rewiring degron network	0.2222
p.P625T	SIDM00773	Non-Cancerous	GDSC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.2778
p.P625T	SIDM00855	Other Sarcomas	GDSC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.2778
p.P625T	SIDM01133	Other Solid Cancers	GDSC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.2778
p.P625T	SIDM00720	Mesothelioma	GDSC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.2778
p.P625T	SIDM01749	Osteosarcoma	GDSC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.2778
p.P625T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.2778
p.Q285R	SIDM01045	Endometrial Carcinoma	GDSC	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.6218
p.Q285R	ACH-000978	Endometrial/Uterine Cancer	CCLE	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.6218
p.Q285R	EN	endometrium	COSMIC	LNQTPLST	DEG_SCF_FBW7_1	283:290	Mutation altering degron motif	0.6218
p.P625L	SIDM00290	Gastric Carcinoma	GDSC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.2778
p.P625L	ACH-000847	Gastric Cancer	CCLE	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.2778
p.P625L	HGC-27	stomach	COSMIC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.2778
p.D620N	SIDM00679	Cervical Carcinoma	GDSC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.1389
p.D620N	ACH-001525	Cervical Cancer	CCLE	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.1389
p.D620N	HT-3	cervix	COSMIC	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.1389
p.N635S	ACH-001335	Cervical Cancer	CCLE	VGTTT	DEG_SPOP_SBC_1	627:631	Mutation rewiring degron network	0.2222

Kaplan plot for ZBTB33 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB33

UniProt ID: Q86T24

Entrez ID: 10009

Protein name: Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB33 in