DegronMD

Uniprot ID: Q86T24

Source protein: Transcriptional regulator Kaiso

Source gene: ZBTB33

Class: DEG_SCF_FBW7_1

Location: 283:290

E3 ligase: FBXW7

DEGRON score: 0.8004

ASA_SCORE: 98.4

COIL: 0.9114

CONS_SCORE: 0.5142

DSS_SCORE: 0.4615

HELIX: 0.0691

FCONS_SCORE: 0.9859

RIG_SCORE: 0.7077

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T290K	TCGA-49-AARO	LUAD	TCGA	LNQTPLST	DEG_SCF_FBW7_1	0.7306
p.T290K	DO218924	LUAD	ICGC	LNQTPLST	DEG_SCF_FBW7_1	0.7306
p.P291Q	TCGA-55-A494	LUAD	TCGA	LNQTPLST	DEG_SCF_FBW7_1	0.3056
p.P291Q	DO23794	LUAD	ICGC	LNQTPLST	DEG_SCF_FBW7_1	0.3056
p.P278T	TCGA-B5-A0K8	UCEC	TCGA	LNQTPLST	DEG_SCF_FBW7_1	0.1944
p.P278T	DO40831	UCEC	ICGC	LNQTPLST	DEG_SCF_FBW7_1	0.1944
p.T290A	TCGA-QL-A97D	COAD	TCGA	LNQTPLST	DEG_SCF_FBW7_1	0.7139
p.T290A	DO51732	COAD	ICGC	LNQTPLST	DEG_SCF_FBW7_1	0.7139
p.V294A	DO232761	PBCA	ICGC	LNQTPLST	DEG_SCF_FBW7_1	0.2222
p.Q285R	SIDM01045	Endometrial Carcinoma	GDSC	LNQTPLST	DEG_SCF_FBW7_1	0.6218
p.Q285R	ACH-000978	Endometrial/Uterine Cancer	CCLE	LNQTPLST	DEG_SCF_FBW7_1	0.6218
p.Q285R	EN	endometrium	COSMIC	LNQTPLST	DEG_SCF_FBW7_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86T24	Transcriptional regulator Kaiso	DEG_SCF_FBW7_1	283:290	LNQTPLST	FBXW7	0.8004	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons