DegronMD - P78316(NOP14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R84I	TCGA-AA-3864	COAD	TCGA	KSNVFRD	LIG_APCC_ABBAyCdc20_2	79:85	Mutation altering degron motif	0.6991
p.R84I	DO8490	COAD	ICGC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	79:85	Mutation altering degron motif	0.6991
p.E76Q	TCGA-AJ-A3QS	UCEC	TCGA	KSNVFRD	LIG_APCC_ABBAyCdc20_2	79:85	Mutation rewiring degron network	0.25
p.E76Q	DO41349	UCEC	ICGC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	79:85	Mutation rewiring degron network	0.25
p.F88C	TCGA-AZ-4315	COAD	TCGA	KSNVFRD	LIG_APCC_ABBAyCdc20_2	79:85	Mutation rewiring degron network	0.25
p.F88C	DO8842	COAD	ICGC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	79:85	Mutation rewiring degron network	0.25
p.G89E	TCGA-B5-A11E	UCEC	TCGA	KSNVFRD	LIG_APCC_ABBAyCdc20_2	79:85	Mutation rewiring degron network	0.2222
p.G89E	DO41644	UCEC	ICGC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	79:85	Mutation rewiring degron network	0.2222
p.R87H	SIDM00217	Colorectal Carcinoma	GDSC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	79:85	Mutation rewiring degron network	0.2778
p.R87H	ACH-000999	Colon/Colorectal Cancer	CCLE	KSNVFRD	LIG_APCC_ABBAyCdc20_2	79:85	Mutation rewiring degron network	0.2778
p.R87H	SNU-1040	large intestine	COSMIC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	79:85	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons