DegronMD

Uniprot ID: P78316

Source protein: Nucleolar protein 14

Source gene: NOP14

Class: LIG_APCC_ABBAyCdc20_2

Location: 79:85

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9991

ASA_SCORE: 78.4571

COIL: 0.6904

CONS_SCORE: 0.5688

DSS_SCORE: 0.4434

HELIX: 0.1253

FCONS_SCORE: 1.0297

RIG_SCORE: 0.7595

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R84I	TCGA-AA-3864	COAD	TCGA	KSNVFRD	LIG_APCC_ABBAyCdc20_2	0.6991
p.R84I	DO8490	COAD	ICGC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	0.6991
p.E76Q	TCGA-AJ-A3QS	UCEC	TCGA	KSNVFRD	LIG_APCC_ABBAyCdc20_2	0.25
p.E76Q	DO41349	UCEC	ICGC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	0.25
p.F88C	TCGA-AZ-4315	COAD	TCGA	KSNVFRD	LIG_APCC_ABBAyCdc20_2	0.25
p.F88C	DO8842	COAD	ICGC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	0.25
p.G89E	TCGA-B5-A11E	UCEC	TCGA	KSNVFRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G89E	DO41644	UCEC	ICGC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R87H	SIDM00217	Colorectal Carcinoma	GDSC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R87H	ACH-000999	Colon/Colorectal Cancer	CCLE	KSNVFRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R87H	SNU-1040	large_intestine	COSMIC	KSNVFRD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78316	Nucleolar protein 14	LIG_APCC_ABBAyCdc20_2	79:85	KSNVFRD	APC,CDC20,FZR1	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons