DegronMD - P78344(EIF4G2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G376V	TCGA-13-1482	OV	TCGA	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.G376V	DO27977	OV	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.R360M	TCGA-A5-A0G2	UCEC	TCGA	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.R360M	DO41235	UCEC	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.M374L	TCGA-AA-A00N	COAD	TCGA	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2778
p.M374L	DO9876	COAD	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2778
p.G382E	TCGA-DX-A8BP	SARC	TCGA	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.G382E	DO220056	SARC	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.D366E	DO229037	LICA	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.5647
p.P358T	DO229041	LICA	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1667
p.R360S	SIDM00864	Cervical Carcinoma	GDSC	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.R360S	ACH-001341	Cervical Cancer	CCLE	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.R360S	DoTc2-4510	cervix	COSMIC	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.M378I	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1667
p.M378I	ACH-000888	Lung Cancer	CCLE	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1667
p.M378I	NCI-H1793	lung	COSMIC	DRDPLGGLA	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1667

Kaplan plot for EIF4G2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EIF4G2

UniProt ID: P78344

Entrez ID: 1982

Protein name: Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EIF4G2 in