DegronMD

Uniprot ID: P78344

Source protein: Eukaryotic translation initiation factor 4 gamma 2

Source gene: EIF4G2

Class: DEG_APCC_DBOX_1

Location: 364:372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9947

ASA_SCORE: 64.3

COIL: 0.8033

CONS_SCORE: 0.506

DSS_SCORE: 0.5359

HELIX: 0.1196

FCONS_SCORE: 1.1582

RIG_SCORE: 0.7246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G376V	TCGA-13-1482	OV	TCGA	DRDPLGGLA	DEG_APCC_DBOX_1	0.2222
p.G376V	DO27977	OV	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	0.2222
p.R360M	TCGA-A5-A0G2	UCEC	TCGA	DRDPLGGLA	DEG_APCC_DBOX_1	0.2222
p.R360M	DO41235	UCEC	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	0.2222
p.M374L	TCGA-AA-A00N	COAD	TCGA	DRDPLGGLA	DEG_APCC_DBOX_1	0.2778
p.M374L	DO9876	COAD	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	0.2778
p.G382E	TCGA-DX-A8BP	SARC	TCGA	DRDPLGGLA	DEG_APCC_DBOX_1	0.0556
p.G382E	DO220056	SARC	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	0.0556
p.D366E	DO229037	LICA	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	0.5647
p.P358T	DO229041	LICA	ICGC	DRDPLGGLA	DEG_APCC_DBOX_1	0.1667
p.R360S	SIDM00864	Cervical Carcinoma	GDSC	DRDPLGGLA	DEG_APCC_DBOX_1	0.2222
p.R360S	ACH-001341	Cervical Cancer	CCLE	DRDPLGGLA	DEG_APCC_DBOX_1	0.2222
p.R360S	DoTc2-4510	cervix	COSMIC	DRDPLGGLA	DEG_APCC_DBOX_1	0.2222
p.M378I	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	DRDPLGGLA	DEG_APCC_DBOX_1	0.1667
p.M378I	ACH-000888	Lung Cancer	CCLE	DRDPLGGLA	DEG_APCC_DBOX_1	0.1667
p.M378I	NCI-H1793	lung	COSMIC	DRDPLGGLA	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78344	Eukaryotic translation initiation factor 4 gamma 2	DEG_APCC_DBOX_1	364:372	DRDPLGGLA	APC,CDC20,FZR1	0.9947	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons