DegronMD - P78396(CCNA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P130S	TCGA-24-1845	OV	TCGA	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.1944
p.G126V	TCGA-FS-A1ZM	SKCM	TCGA	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.0833
p.M139I	TCGA-GN-A269	SKCM	TCGA	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation altering degron motif	0.6507
p.R147K	TCGA-GN-A26C	SKCM	TCGA	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.1389
p.D140N	TCGA-GN-A4U4	SKCM	TCGA	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation altering degron motif	0.6932
p.Q133K	TCGA-LI-A9QH	SARC	TCGA	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.2778
p.G134R	TCGA-VQ-A8PP	STAD	TCGA	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.3056
p.D128H	DO48428	BLCA	ICGC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.1389
p.V143I	DO540	BLCA	ICGC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.25
p.C149Y	DO234357	ESAD	ICGC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.0833
p.G125A	DO23474	LINC	ICGC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.0556
p.L147I	DO46657	PAAD	ICGC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.1389
p.P140S	DO37519	SKCM	ICGC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation altering degron motif	0.6752
p.M138I	DO37483	SKCM	ICGC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation altering degron motif	0.7618
p.L125F	DO51785	STAD	ICGC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.0556
p.G133R	DO51774	STAD	ICGC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.2778
p.D136H	SIDM01120	Other Solid Cancers	GDSC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation altering degron motif	0.6577
p.D136H	ACH-002174	Lung Cancer	CCLE	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation altering degron motif	0.6577
p.D136H	NCI-H720	lung	COSMIC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation altering degron motif	0.6577
p.P130H	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.1944
p.P130H	ACH-000912	Lung Cancer	CCLE	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.1944
p.G134V	ACH-001518	Endometrial/Uterine Cancer	CCLE	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.3056
p.E141K	ACH-001970	Metastasis	CCLE	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.3056
p.H130Y	23132-87	stomach	COSMIC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation rewiring degron network	0.1944
p.D135H	NCI-H720	lung	COSMIC	FDIYMD	LIG_APCC_ABBA_1	135:140	Mutation altering degron motif	0.7688

Kaplan plot for CCNA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCNA1

UniProt ID: P78396

Entrez ID: 8900

Protein name: Cyclin-A1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCNA1 in