DegronMD

Uniprot ID: P78396

Source protein: Cyclin-A1

Source gene: CCNA1

Class: LIG_APCC_ABBA_1

Location: 135:140

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9598

ASA_SCORE: 82.3833

COIL: 0.4647

CONS_SCORE: 0.434

DSS_SCORE: 0.5994

HELIX: 0.0785

FCONS_SCORE: 1.0912

RIG_SCORE: 0.8211

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P130S	TCGA-24-1845	OV	TCGA	FDIYMD	LIG_APCC_ABBA_1	0.1944
p.G126V	TCGA-FS-A1ZM	SKCM	TCGA	FDIYMD	LIG_APCC_ABBA_1	0.0833
p.M139I	TCGA-GN-A269	SKCM	TCGA	FDIYMD	LIG_APCC_ABBA_1	0.6507
p.R147K	TCGA-GN-A26C	SKCM	TCGA	FDIYMD	LIG_APCC_ABBA_1	0.1389
p.D140N	TCGA-GN-A4U4	SKCM	TCGA	FDIYMD	LIG_APCC_ABBA_1	0.6932
p.Q133K	TCGA-LI-A9QH	SARC	TCGA	FDIYMD	LIG_APCC_ABBA_1	0.2778
p.G134R	TCGA-VQ-A8PP	STAD	TCGA	FDIYMD	LIG_APCC_ABBA_1	0.3056
p.D128H	DO48428	BLCA	ICGC	FDIYMD	LIG_APCC_ABBA_1	0.1389
p.V143I	DO540	BLCA	ICGC	FDIYMD	LIG_APCC_ABBA_1	0.25
p.C149Y	DO234357	ESAD	ICGC	FDIYMD	LIG_APCC_ABBA_1	0.0833
p.G125A	DO23474	LINC	ICGC	FDIYMD	LIG_APCC_ABBA_1	0.0556
p.L147I	DO46657	PAAD	ICGC	FDIYMD	LIG_APCC_ABBA_1	0.1389
p.P140S	DO37519	SKCM	ICGC	FDIYMD	LIG_APCC_ABBA_1	0.6752
p.M138I	DO37483	SKCM	ICGC	FDIYMD	LIG_APCC_ABBA_1	0.7618
p.L125F	DO51785	STAD	ICGC	FDIYMD	LIG_APCC_ABBA_1	0.0556
p.G133R	DO51774	STAD	ICGC	FDIYMD	LIG_APCC_ABBA_1	0.2778
p.D136H	SIDM01120	Other Solid Cancers	GDSC	FDIYMD	LIG_APCC_ABBA_1	0.6577
p.D136H	ACH-002174	Lung Cancer	CCLE	FDIYMD	LIG_APCC_ABBA_1	0.6577
p.D136H	NCI-H720	lung	COSMIC	FDIYMD	LIG_APCC_ABBA_1	0.6577
p.P130H	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	FDIYMD	LIG_APCC_ABBA_1	0.1944
p.P130H	ACH-000912	Lung Cancer	CCLE	FDIYMD	LIG_APCC_ABBA_1	0.1944
p.G134V	ACH-001518	Endometrial/Uterine Cancer	CCLE	FDIYMD	LIG_APCC_ABBA_1	0.3056
p.E141K	ACH-001970	Metastasis	CCLE	FDIYMD	LIG_APCC_ABBA_1	0.3056
p.H130Y	23132-87	stomach	COSMIC	FDIYMD	LIG_APCC_ABBA_1	0.1944
p.D135H	NCI-H720	lung	COSMIC	FDIYMD	LIG_APCC_ABBA_1	0.7688

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78396	Cyclin-A1	LIG_APCC_ABBA_1	135:140	FDIYMD	APC,CDC20,FZR1	0.9598	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons