DegronMD - P78406(RAE1)

RAE1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A219S	TCGA-A5-A0G2	UCEC	TCGA	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.6477
p.A219S	DO41235	UCEC	ICGC	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.6477
p.K227T	TCGA-BR-8589	STAD	TCGA	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation blocking ubiquitination signal	0.6667
p.K227T	DO47813	STAD	ICGC	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation blocking ubiquitination signal	0.6667
p.N226K	TCGA-CH-5762	PRAD	TCGA	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.25
p.N226K	DO36228	PRAD	ICGC	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.25
p.R216W	TCGA-EO-A22R	UCEC	TCGA	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.2778
p.R216W	DO42713	UCEC	ICGC	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.2778
p.R216Q	TCGA-EO-A3AU	UCEC	TCGA	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.2778
p.R216Q	DO43827	UCEC	ICGC	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.2778
p.T229I	DO52456	COCA	ICGC	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation blocking phosphorylation signal	0.6111
p.A219V	DO233935	GACA	ICGC	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.5825
p.D223Y	DO228900	LICA	ICGC	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.7325
p.A232S	DO228985	LICA	ICGC	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.0833
p.C217R	ACH-001991	Primary	CCLE	VAIFKD	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc