DegronMD

Uniprot ID: P78406

Source protein: mRNA export factor RAE1

Source gene: RAE1

Class: LIG_APCC_ABBA_1

Location: 218:223

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6299

ASA_SCORE: 19.7333

COIL: 0.1857

CONS_SCORE: 0.5852

DSS_SCORE: 0.4092

HELIX: 0.0037

FCONS_SCORE: 1.021

RIG_SCORE: 0.845

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A219S	TCGA-A5-A0G2	UCEC	TCGA	VAIFKD	LIG_APCC_ABBA_1	0.6477
p.A219S	DO41235	UCEC	ICGC	VAIFKD	LIG_APCC_ABBA_1	0.6477
p.K227T	TCGA-BR-8589	STAD	TCGA	VAIFKD	LIG_APCC_ABBA_1	0.6667
p.K227T	DO47813	STAD	ICGC	VAIFKD	LIG_APCC_ABBA_1	0.6667
p.N226K	TCGA-CH-5762	PRAD	TCGA	VAIFKD	LIG_APCC_ABBA_1	0.25
p.N226K	DO36228	PRAD	ICGC	VAIFKD	LIG_APCC_ABBA_1	0.25
p.R216W	TCGA-EO-A22R	UCEC	TCGA	VAIFKD	LIG_APCC_ABBA_1	0.2778
p.R216W	DO42713	UCEC	ICGC	VAIFKD	LIG_APCC_ABBA_1	0.2778
p.R216Q	TCGA-EO-A3AU	UCEC	TCGA	VAIFKD	LIG_APCC_ABBA_1	0.2778
p.R216Q	DO43827	UCEC	ICGC	VAIFKD	LIG_APCC_ABBA_1	0.2778
p.T229I	DO52456	COCA	ICGC	VAIFKD	LIG_APCC_ABBA_1	0.6111
p.A219V	DO233935	GACA	ICGC	VAIFKD	LIG_APCC_ABBA_1	0.5825
p.D223Y	DO228900	LICA	ICGC	VAIFKD	LIG_APCC_ABBA_1	0.7325
p.A232S	DO228985	LICA	ICGC	VAIFKD	LIG_APCC_ABBA_1	0.0833
p.C217R	ACH-001991	Primary	CCLE	VAIFKD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78406	mRNA export factor RAE1	LIG_APCC_ABBA_1	218:223	VAIFKD	APC,CDC20,FZR1	0.6299	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons