IRX3
UniProt ID: P78415
Entrez ID: 79191
Protein name: Iroquois-class homeodomain protein IRX-3 (Homeodomain protein IRXB1) (Iroquois homeobox protein 3)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signal...
FUNCTION: Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. {ECO:0000250|UniProtKB:P81067}.
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GO - Biological processes (BP):
atrioventricular bundle cell differentiation [GO:0003167]; cell development [GO:0048468]; energy homeostasis [GO:0097009]; His-Purkinje system cell differentiation [GO:0060932]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of neuron differentiation [GO...
atrioventricular bundle cell differentiation [GO:0003167]; cell development [GO:0048468]; energy homeostasis [GO:0097009]; His-Purkinje system cell differentiation [GO:0060932]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Purkinje myocyte development [GO:0003165]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of loop of Henle identity [GO:0072086]
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GO - Molecular function (MF):
DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region se...
DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]
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GO - Cellular component (CC):
axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]...
axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]
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IRX3
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Kaplan plot for IRX3 in
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*NOTE: the Kaplan plots were collected from OncoLnc