DegronMD

Uniprot ID: P78415

Source protein: Iroquois-class homeodomain protein IRX-3

Source gene: IRX3

Class: DEG_SIAH_1

Location: 373:381

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9993

ASA_SCORE: 76.3333

COIL: 0.8144

CONS_SCORE: 0.4049

DSS_SCORE: 0.5705

HELIX: 0.1536

FCONS_SCORE: 1.0356

RIG_SCORE: 0.6077

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A379T	DO222919	BTCA	ICGC	PPGAAVAPS	DEG_SIAH_1	0.6028
p.P380L	DO222437	ESCA	ICGC	PPGAAVAPS	DEG_SIAH_1	0.7582
p.A389T	DO233115	GACA	ICGC	PPGAAVAPS	DEG_SIAH_1	0.1111
p.A388V	DO229218	THCA	ICGC	PPGAAVAPS	DEG_SIAH_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75312	Zinc finger protein ZPR1	DEG_SIAH_1	11:19	PPGAAVAPS	SIAH1,SIAH2,SIAH3	0.963	More...
P78415	Iroquois-class homeodomain protein IRX-3	DEG_SIAH_1	373:381	PPGAAVAPS	SIAH1,SIAH2,SIAH3	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons