DegronMD

Uniprot ID: O75312

Source protein: Zinc finger protein ZPR1

Source gene: ZPR1

Class: DEG_SIAH_1

Location: 11:19

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.963

ASA_SCORE: 71.0667

COIL: 0.8889

CONS_SCORE: 0.1878

DSS_SCORE: 0.6851

HELIX: 0.0629

FCONS_SCORE: 0.8803

RIG_SCORE: 0.5341

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P11L	SIDM01047	Chronic Myelogenous Leukemia	GDSC	PPGAAVAPS	DEG_SIAH_1	0.6471
p.A21V	SIDM00719	Small Cell Lung Carcinoma	GDSC	PPGAAVAPS	DEG_SIAH_1	0.2778
p.A21V	SIDM00696	Non-Cancerous	GDSC	PPGAAVAPS	DEG_SIAH_1	0.2778
p.A21V	SIDM00772	Breast Carcinoma	GDSC	PPGAAVAPS	DEG_SIAH_1	0.2778
p.A21V	SIDM00382	Glioblastoma	GDSC	PPGAAVAPS	DEG_SIAH_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75312	Zinc finger protein ZPR1	DEG_SIAH_1	11:19	PPGAAVAPS	SIAH1,SIAH2,SIAH3	0.963	More...
P78415	Iroquois-class homeodomain protein IRX-3	DEG_SIAH_1	373:381	PPGAAVAPS	SIAH1,SIAH2,SIAH3	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons