DegronMD - P78504(JAG1)

GO - Biological processes (BP): angiogenesis [GO:0001525]; aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; blood vessel remodeling [GO:0001974]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cell fate determination [GO:0001709]; ciliary body morphogenesis [GO:0061073]; distal tubule development [GO:0072017]; endocardial cushion cell development [GO:0061444]; endothelial cell differentiation [GO:0045446]; glomerular visceral epithelial cell development [GO:0072015]; hemopoiesis [GO:0030097]; inner ear auditory receptor cell differentiation [GO:0042491]; keratinocyte differentiation [GO:0030216]; loop of Henle development [GO:0072070]; morphogenesis of an epithelial sheet [GO:0002011]; myoblast differentiation [GO:0045445]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of stem cell differentiation [GO:2000737]; nephron development [GO:0072006]; nervous system development [GO:0007399]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of cell population proliferation [GO:0042127]; response to muramyl dipeptide [GO:0032495]; T cell mediated immunity [GO:0002456] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1126T	TCGA-2A-AAYO	PRAD	TCGA	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.25
p.G1130R	TCGA-56-7730	LUSC	TCGA	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.1389
p.P1125H	TCGA-AA-A01T	COAD	TCGA	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.2778
p.A1131T	TCGA-AZ-4315	COAD	TCGA	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.1111
p.Q1121K	SIDM00365	Small Cell Lung Carcinoma	GDSC	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.5833
p.Q1121K	ACH-002196	Lung Cancer	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.5833
p.Q1121K	SBC-1	lung	COSMIC	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.5833
p.E1127K	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.2222
p.E1127K	ACH-000937	Leukemia	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.2222
p.E1127K	PF-382	haematopoietic and lymphoid tissue	COSMIC	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.2222
p.R1116W	SIDM00839	Colorectal Carcinoma	GDSC	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.8634
p.R1116W	ACH-000950	Colon/Colorectal Cancer	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.8634
p.R1116W	LoVo	large intestine	COSMIC	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.8634
p.V1115M	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.6097
p.V1115M	ACH-000285	Lymphoma	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.6097
p.N1124S	SIDM01424	B-Lymphoblastic Leukemia	GDSC	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.3056
p.N1124S	ACH-000782	Leukemia	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.3056
p.N1124S	ACH-001735	Leukemia	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.3056

Kaplan plot for JAG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JAG1

UniProt ID: P78504

Entrez ID: 182

Protein name: Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JAG1 in