DegronMD

Uniprot ID: P78504

Source protein: Protein jagged-1

Source gene: JAG1

Class: DEG_APCC_DBOX_1

Location: 1115:1123

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9293

ASA_SCORE: 92.0778

COIL: 0.4824

CONS_SCORE: 0.4167

DSS_SCORE: 0.6478

HELIX: 0.497

FCONS_SCORE: 1.0357

RIG_SCORE: 0.7421

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1126T	TCGA-2A-AAYO	PRAD	TCGA	VREQLNQIK	DEG_APCC_DBOX_1	0.25
p.G1130R	TCGA-56-7730	LUSC	TCGA	VREQLNQIK	DEG_APCC_DBOX_1	0.1389
p.P1125H	TCGA-AA-A01T	COAD	TCGA	VREQLNQIK	DEG_APCC_DBOX_1	0.2778
p.A1131T	TCGA-AZ-4315	COAD	TCGA	VREQLNQIK	DEG_APCC_DBOX_1	0.1111
p.Q1121K	SIDM00365	Small Cell Lung Carcinoma	GDSC	VREQLNQIK	DEG_APCC_DBOX_1	0.5833
p.Q1121K	ACH-002196	Lung Cancer	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	0.5833
p.Q1121K	SBC-1	lung	COSMIC	VREQLNQIK	DEG_APCC_DBOX_1	0.5833
p.E1127K	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VREQLNQIK	DEG_APCC_DBOX_1	0.2222
p.E1127K	ACH-000937	Leukemia	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	0.2222
p.E1127K	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VREQLNQIK	DEG_APCC_DBOX_1	0.2222
p.R1116W	SIDM00839	Colorectal Carcinoma	GDSC	VREQLNQIK	DEG_APCC_DBOX_1	0.8634
p.R1116W	ACH-000950	Colon/Colorectal Cancer	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	0.8634
p.R1116W	LoVo	large_intestine	COSMIC	VREQLNQIK	DEG_APCC_DBOX_1	0.8634
p.V1115M	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	VREQLNQIK	DEG_APCC_DBOX_1	0.6097
p.V1115M	ACH-000285	Lymphoma	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	0.6097
p.N1124S	SIDM01424	B-Lymphoblastic Leukemia	GDSC	VREQLNQIK	DEG_APCC_DBOX_1	0.3056
p.N1124S	ACH-000782	Leukemia	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	0.3056
p.N1124S	ACH-001735	Leukemia	CCLE	VREQLNQIK	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78504	Protein jagged-1	DEG_APCC_DBOX_1	1115:1123	VREQLNQIK	APC,CDC20,FZR1	0.9293	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons