DegronMD - P81133(SIM1)

SIM1

UniProt ID: P81133

Entrez ID: 6492

Protein name: Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S680L	TCGA-12-1602	GBM	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation altering degron motif	0.6556
p.S680L	TCGA-B5-A11E	UCEC	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation altering degron motif	0.6556
p.S680L	DO11034	GBM	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation altering degron motif	0.6556
p.S680L	DO41644	UCEC	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation altering degron motif	0.6556
p.H685R	TCGA-CG-5728	STAD	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.2222
p.H685R	DO38619	STAD	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.2222
p.H685Y	TCGA-D3-A8GL	SKCM	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.2222
p.H685Y	DO50287	SKCM	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.2222
p.R665C	TCGA-EE-A2MD	SKCM	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.0556
p.R665C	DO222434	MELA	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.0556
p.R665C	DO37851	SKCM	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.0556
p.D676E	TCGA-EO-A22R	UCEC	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation altering degron motif	0.5647
p.D676E	DO42713	UCEC	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation altering degron motif	0.5647
p.S669F	DO233089	GACA	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.1667
p.S669F	DO220899	MELA	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.1667
p.R665H	DO229480	LAML	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.0556
p.R665H	DO231075	LUSC	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.0556
p.R665H	SIDM00235	Kidney Carcinoma	GDSC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.0556
p.R665H	SIDM00618	Hepatocellular Carcinoma	GDSC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.0556
p.R665H	SIDM01460	Glioma	GDSC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.0556
p.D676V	DO46513	OV	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation altering degron motif	0.6674
p.S667L	SIDM00234	Other Solid Cancers	GDSC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.1111
p.S667L	ACH-002201	Cervical Cancer	CCLE	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.1111
p.S667L	TC-YIK	cervix	COSMIC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.1111
p.I666V	SIDM00377	Other Sarcomas	GDSC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.0833
p.I666V	ACH-001655	Endometrial/Uterine Cancer	CCLE	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.0833
p.I666V	SKN	soft tissue	COSMIC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	675:681	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc