DegronMD

Uniprot ID: P81133

Source protein: Single-minded homolog 1

Source gene: SIM1

Class: LIG_APCC_ABBAyCdc20_2

Location: 675:681

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6077

ASA_SCORE: 85.8

COIL: 0.6269

CONS_SCORE: 0.5386

DSS_SCORE: 0.4092

HELIX: 0.232

FCONS_SCORE: 1.0335

RIG_SCORE: 0.7281

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S680L	TCGA-12-1602	GBM	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.6556
p.S680L	TCGA-B5-A11E	UCEC	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.6556
p.S680L	DO11034	GBM	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.6556
p.S680L	DO41644	UCEC	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.6556
p.H685R	TCGA-CG-5728	STAD	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.H685R	DO38619	STAD	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.H685Y	TCGA-D3-A8GL	SKCM	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.H685Y	DO50287	SKCM	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R665C	TCGA-EE-A2MD	SKCM	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R665C	DO222434	MELA	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R665C	DO37851	SKCM	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D676E	TCGA-EO-A22R	UCEC	TCGA	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.5647
p.D676E	DO42713	UCEC	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.5647
p.S669F	DO233089	GACA	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S669F	DO220899	MELA	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R665H	DO229480	LAML	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R665H	DO231075	LUSC	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R665H	SIDM00235	Kidney Carcinoma	GDSC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R665H	SIDM00618	Hepatocellular Carcinoma	GDSC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R665H	SIDM01460	Glioma	GDSC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D676V	DO46513	OV	ICGC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.6674
p.S667L	SIDM00234	Other Solid Cancers	GDSC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.S667L	ACH-002201	Cervical Cancer	CCLE	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.S667L	TC-YIK	cervix	COSMIC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.I666V	SIDM00377	Other Sarcomas	GDSC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.I666V	ACH-001655	Endometrial/Uterine Cancer	CCLE	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.I666V	SKN	soft_tissue	COSMIC	KDYLHSD	LIG_APCC_ABBAyCdc20_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KDYLHSD

Degron related mutations and impact score

Drug responses associated with SIM1 mutations

All proteins holding degron of KDYLHSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P81133	Single-minded homolog 1	LIG_APCC_ABBAyCdc20_2	675:681	KDYLHSD	APC,CDC20,FZR1	0.6077	More...