DegronMD - P81277(PRLH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K65N	TCGA-95-A4VN	LUAD	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.3056
p.K65N	DO51199	LUAD	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.3056
p.G51S	TCGA-A5-A0G2	UCEC	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1944
p.G51S	DO41235	UCEC	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1944
p.R69Q	TCGA-AP-A0LM	UCEC	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1944
p.R69Q	TCGA-EB-A41B	SKCM	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1944
p.R69Q	DO37611	SKCM	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1944
p.R69Q	DO43306	UCEC	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1944
p.R69Q	SIDM00697	Small Cell Lung Carcinoma	GDSC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1944
p.R69Q	NCI-H1436	lung	COSMIC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1944
p.G46R	TCGA-B5-A11F	UCEC	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.0556
p.G46R	DO43618	UCEC	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.0556
p.R55W	TCGA-EY-A549	UCEC	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.3056
p.R55W	DO48174	UCEC	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.3056
p.G46W	TCGA-FS-A1ZG	SKCM	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.0556
p.G46W	DO37523	SKCM	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.0556
p.P49T	DO228461	LICA	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1389
p.R55Q	DO220862	MELA	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.3056
p.R55Q	SIDM00082	Melanoma	GDSC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.3056
p.R55Q	ACH-001190	Skin Cancer	CCLE	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.3056
p.R55Q	SK-MEL-2	skin	COSMIC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.3056
p.R48K	DO220875	MELA	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1111
p.P66L	SIDM01190	Bladder Carcinoma	GDSC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.2778
p.P66L	ACH-000720	Bladder Cancer	CCLE	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.2778
p.P66L	TCCSUP	urinary tract	COSMIC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.2778
p.R71W	SIDM00451	T-Lymphoblastic Leukemia	GDSC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1389
p.R71W	ACH-000937	Leukemia	CCLE	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1389
p.R71W	PF-382	haematopoietic and lymphoid tissue	COSMIC	RRATLGDVP	DEG_APCC_DBOX_1	56:64	Mutation rewiring degron network	0.1389

Kaplan plot for PRLH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRLH

UniProt ID: P81277

Entrez ID: 51052

Protein name: Prolactin-releasing peptide (PrRP) (Prolactin-releasing hormone) [Cleaved into: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRLH in