DegronMD

Uniprot ID: P81277

Source protein: Prolactin-releasing peptide

Source gene: PRLH

Class: DEG_APCC_DBOX_1

Location: 56:64

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6699

ASA_SCORE: 86.7333

COIL: 0.7247

CONS_SCORE: 0.4906

DSS_SCORE: 0.5076

HELIX: 0.084

FCONS_SCORE: 0.7469

RIG_SCORE: 0.7233

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K65N	TCGA-95-A4VN	LUAD	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	0.3056
p.K65N	DO51199	LUAD	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	0.3056
p.G51S	TCGA-A5-A0G2	UCEC	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	0.1944
p.G51S	DO41235	UCEC	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	0.1944
p.R69Q	TCGA-AP-A0LM	UCEC	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	0.1944
p.R69Q	TCGA-EB-A41B	SKCM	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	0.1944
p.R69Q	DO37611	SKCM	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	0.1944
p.R69Q	DO43306	UCEC	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	0.1944
p.R69Q	SIDM00697	Small Cell Lung Carcinoma	GDSC	RRATLGDVP	DEG_APCC_DBOX_1	0.1944
p.R69Q	NCI-H1436	lung	COSMIC	RRATLGDVP	DEG_APCC_DBOX_1	0.1944
p.G46R	TCGA-B5-A11F	UCEC	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	0.0556
p.G46R	DO43618	UCEC	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	0.0556
p.R55W	TCGA-EY-A549	UCEC	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	0.3056
p.R55W	DO48174	UCEC	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	0.3056
p.G46W	TCGA-FS-A1ZG	SKCM	TCGA	RRATLGDVP	DEG_APCC_DBOX_1	0.0556
p.G46W	DO37523	SKCM	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	0.0556
p.P49T	DO228461	LICA	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	0.1389
p.R55Q	DO220862	MELA	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	0.3056
p.R55Q	SIDM00082	Melanoma	GDSC	RRATLGDVP	DEG_APCC_DBOX_1	0.3056
p.R55Q	ACH-001190	Skin Cancer	CCLE	RRATLGDVP	DEG_APCC_DBOX_1	0.3056
p.R55Q	SK-MEL-2	skin	COSMIC	RRATLGDVP	DEG_APCC_DBOX_1	0.3056
p.R48K	DO220875	MELA	ICGC	RRATLGDVP	DEG_APCC_DBOX_1	0.1111
p.P66L	SIDM01190	Bladder Carcinoma	GDSC	RRATLGDVP	DEG_APCC_DBOX_1	0.2778
p.P66L	ACH-000720	Bladder Cancer	CCLE	RRATLGDVP	DEG_APCC_DBOX_1	0.2778
p.P66L	TCCSUP	urinary_tract	COSMIC	RRATLGDVP	DEG_APCC_DBOX_1	0.2778
p.R71W	SIDM00451	T-Lymphoblastic Leukemia	GDSC	RRATLGDVP	DEG_APCC_DBOX_1	0.1389
p.R71W	ACH-000937	Leukemia	CCLE	RRATLGDVP	DEG_APCC_DBOX_1	0.1389
p.R71W	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	RRATLGDVP	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRATLGDVP

Degron related mutations and impact score

Drug responses associated with PRLH mutations

All proteins holding degron of RRATLGDVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P81277	Prolactin-releasing peptide	DEG_APCC_DBOX_1	56:64	RRATLGDVP	APC,CDC20,FZR1	0.6699	More...