DegronMD - P98073(TMPRSS15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P510R	TCGA-28-5219	GBM	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.2778
p.P510R	DO11178	GBM	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.2778
p.G504E	TCGA-33-4566	LUSC	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1111
p.G504E	DO26790	LUSC	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1111
p.G504E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1111
p.G504E	SIDM00539	Esophageal Carcinoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1111
p.G504E	SIDM00882	Breast Carcinoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1111
p.G504E	SIDM00863	Burkitt's Lymphoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1111
p.P527H	TCGA-44-8120	LUAD	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1111
p.P527H	DO45402	LUAD	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1111
p.L506I	TCGA-49-4494	LUAD	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1667
p.L506I	DO24245	LUAD	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1667
p.P510T	TCGA-55-A48X	LUAD	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.2778
p.P510T	DO24048	LUAD	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.2778
p.C502Y	TCGA-86-8673	LUAD	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.0556
p.C502Y	DO26260	LUAD	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.0556
p.L512F	TCGA-98-A53A	LUSC	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation altering degron motif	0.6981
p.L512F	DO219178	LUSC	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation altering degron motif	0.6981
p.L506H	TCGA-A8-A06X	BRCA	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1667
p.L506H	DO5074	BRCA	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1667
p.T522M	TCGA-AJ-A3BH	UCEC	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.25
p.T522M	DO41638	UCEC	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.25
p.T522M	SIDM00798	Rhabdomyosarcoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.25
p.P508S	TCGA-D3-A2JF	SKCM	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.2222
p.P508S	DO38153	SKCM	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.2222
p.G504W	TCGA-ER-A195	SKCM	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1111
p.G504W	DO47712	SKCM	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1111
p.L506F	TCGA-FW-A3R5	SKCM	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1667
p.L506F	DO37406	SKCM	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1667
p.P518Q	TCGA-O2-A52Q	LUSC	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation altering degron motif	0.5924
p.P518Q	DO219219	LUSC	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation altering degron motif	0.5924
p.P508Q	DO1195	BRCA	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.2222
p.T511N	DO222953	BTCA	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.3056
p.E529Q	DO10172	COAD	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.0556
p.P527L	DO228649	GACA	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1111
p.C524Y	DO45073	LINC	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.1944
p.T511P	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.3056
p.T511P	ACH-000510	Lung Cancer	CCLE	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.3056
p.T511P	NCI-H1299	lung	COSMIC	LVPTPPPE	DEG_SCF_FBW7_2	512:519	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMPRSS15

UniProt ID: P98073

Entrez ID: 5651

Protein name: Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMPRSS15 in