DegronMD

Uniprot ID: P98073

Source protein: Enteropeptidase

Source gene: TMPRSS15

Class: DEG_SCF_FBW7_2

Location: 512:519

E3 ligase: FBXW7

DEGRON score: 0.8324

ASA_SCORE: 82.4375

COIL: 0.9609

CONS_SCORE: 0.2655

DSS_SCORE: 0.5616

HELIX: 0.0095

FCONS_SCORE: 0.5839

RIG_SCORE: 0.692

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P510R	TCGA-28-5219	GBM	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.2778
p.P510R	DO11178	GBM	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.2778
p.G504E	TCGA-33-4566	LUSC	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.1111
p.G504E	DO26790	LUSC	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.1111
p.G504E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	0.1111
p.G504E	SIDM00539	Esophageal Carcinoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	0.1111
p.G504E	SIDM00882	Breast Carcinoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	0.1111
p.G504E	SIDM00863	Burkitt's Lymphoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	0.1111
p.P527H	TCGA-44-8120	LUAD	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.1111
p.P527H	DO45402	LUAD	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.1111
p.L506I	TCGA-49-4494	LUAD	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.1667
p.L506I	DO24245	LUAD	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.1667
p.P510T	TCGA-55-A48X	LUAD	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.2778
p.P510T	DO24048	LUAD	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.2778
p.C502Y	TCGA-86-8673	LUAD	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.0556
p.C502Y	DO26260	LUAD	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.0556
p.L512F	TCGA-98-A53A	LUSC	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.6981
p.L512F	DO219178	LUSC	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.6981
p.L506H	TCGA-A8-A06X	BRCA	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.1667
p.L506H	DO5074	BRCA	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.1667
p.T522M	TCGA-AJ-A3BH	UCEC	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.25
p.T522M	DO41638	UCEC	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.25
p.T522M	SIDM00798	Rhabdomyosarcoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	0.25
p.P508S	TCGA-D3-A2JF	SKCM	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.2222
p.P508S	DO38153	SKCM	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.2222
p.G504W	TCGA-ER-A195	SKCM	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.1111
p.G504W	DO47712	SKCM	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.1111
p.L506F	TCGA-FW-A3R5	SKCM	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.1667
p.L506F	DO37406	SKCM	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.1667
p.P518Q	TCGA-O2-A52Q	LUSC	TCGA	LVPTPPPE	DEG_SCF_FBW7_2	0.5924
p.P518Q	DO219219	LUSC	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.5924
p.P508Q	DO1195	BRCA	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.2222
p.T511N	DO222953	BTCA	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.3056
p.E529Q	DO10172	COAD	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.0556
p.P527L	DO228649	GACA	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.1111
p.C524Y	DO45073	LINC	ICGC	LVPTPPPE	DEG_SCF_FBW7_2	0.1944
p.T511P	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	LVPTPPPE	DEG_SCF_FBW7_2	0.3056
p.T511P	ACH-000510	Lung Cancer	CCLE	LVPTPPPE	DEG_SCF_FBW7_2	0.3056
p.T511P	NCI-H1299	lung	COSMIC	LVPTPPPE	DEG_SCF_FBW7_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LVPTPPPE

Degron related mutations and impact score

Drug responses associated with TMPRSS15 mutations

All proteins holding degron of LVPTPPPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98073	Enteropeptidase	DEG_SCF_FBW7_2	512:519	LVPTPPPE	FBXW7	0.8324	More...