DegronMD - P98095(FBLN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L559V	TCGA-A8-A06Q	BRCA	TCGA	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation altering degron motif	0.5654
p.L559V	DO1263	BRCA	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation altering degron motif	0.5654
p.R565C	TCGA-BR-6458	STAD	TCGA	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.3056
p.R565C	DO220891	MELA	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.3056
p.R565C	DO38296	STAD	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.3056
p.R565C	SIDM00945	Colorectal Carcinoma	GDSC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.3056
p.R565C	ACH-000895	Colon/Colorectal Cancer	CCLE	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.3056
p.R565C	CL-34	large intestine	COSMIC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.3056
p.R565H	TCGA-BR-8680	STAD	TCGA	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.3056
p.R565H	TCGA-VQ-A91D	STAD	TCGA	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.3056
p.R565H	DO51783	STAD	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.3056
p.R565H	DO47769	STAD	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.3056
p.C552F	TCGA-CG-5733	STAD	TCGA	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2778
p.C552F	DO228971	LICA	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2778
p.C552F	DO38551	STAD	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2778
p.R566Q	TCGA-D1-A17Q	UCEC	TCGA	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2778
p.R566Q	TCGA-E6-A1LX	UCEC	TCGA	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2778
p.R566Q	TCGA-XV-AAZV	SKCM	TCGA	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2778
p.R566Q	DO220872	MELA	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2778
p.R566Q	DO219493	SKCM	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2778
p.R566Q	DO41020	UCEC	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2778
p.R566Q	DO41903	UCEC	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2778
p.E563K	TCGA-EE-A20C	SKCM	TCGA	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation altering degron motif	0.7022
p.E563K	DO222775	MELA	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation altering degron motif	0.7022
p.E563K	DO47665	SKCM	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation altering degron motif	0.7022
p.V561L	TCGA-EE-A3AA	SKCM	TCGA	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation altering degron motif	0.6765
p.V561L	DO37571	SKCM	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation altering degron motif	0.6765
p.N546K	DO218333	BRCA	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.1111
p.V548F	DO229019	LICA	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.1667
p.C553F	DO229025	LICA	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.3056
p.C545F	DO229006	LICA	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.0833
p.P568T	DO46897	RECA	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2222
p.P568Q	DO46897	RECA	ICGC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.2222
p.A571V	SIDM00839	Colorectal Carcinoma	GDSC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.1389
p.A571V	ACH-000950	Colon/Colorectal Cancer	CCLE	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.1389
p.A571V	LoVo	large intestine	COSMIC	EGEEPLIVPEV	DEG_COP1_1	554:564	Mutation rewiring degron network	0.1389

Kaplan plot for FBLN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBLN2

UniProt ID: P98095

Entrez ID: 2199

Protein name: Fibulin-2 (FIBL-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBLN2 in