DegronMD

Uniprot ID: P98095

Source protein: Fibulin-2

Source gene: FBLN2

Class: DEG_COP1_1

Location: 554:564

E3 ligase: COP1

DEGRON score: 0.5208

ASA_SCORE: 76.6182

COIL: 0.6392

CONS_SCORE: 0.9333

DSS_SCORE: 0.331

HELIX: 0.092

FCONS_SCORE: 1.0773

RIG_SCORE: 0.7522

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L559V	TCGA-A8-A06Q	BRCA	TCGA	EGEEPLIVPEV	DEG_COP1_1	0.5654
p.L559V	DO1263	BRCA	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.5654
p.R565C	TCGA-BR-6458	STAD	TCGA	EGEEPLIVPEV	DEG_COP1_1	0.3056
p.R565C	DO220891	MELA	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.3056
p.R565C	DO38296	STAD	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.3056
p.R565C	SIDM00945	Colorectal Carcinoma	GDSC	EGEEPLIVPEV	DEG_COP1_1	0.3056
p.R565C	ACH-000895	Colon/Colorectal Cancer	CCLE	EGEEPLIVPEV	DEG_COP1_1	0.3056
p.R565C	CL-34	large_intestine	COSMIC	EGEEPLIVPEV	DEG_COP1_1	0.3056
p.R565H	TCGA-BR-8680	STAD	TCGA	EGEEPLIVPEV	DEG_COP1_1	0.3056
p.R565H	TCGA-VQ-A91D	STAD	TCGA	EGEEPLIVPEV	DEG_COP1_1	0.3056
p.R565H	DO51783	STAD	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.3056
p.R565H	DO47769	STAD	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.3056
p.C552F	TCGA-CG-5733	STAD	TCGA	EGEEPLIVPEV	DEG_COP1_1	0.2778
p.C552F	DO228971	LICA	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.2778
p.C552F	DO38551	STAD	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.2778
p.R566Q	TCGA-D1-A17Q	UCEC	TCGA	EGEEPLIVPEV	DEG_COP1_1	0.2778
p.R566Q	TCGA-E6-A1LX	UCEC	TCGA	EGEEPLIVPEV	DEG_COP1_1	0.2778
p.R566Q	TCGA-XV-AAZV	SKCM	TCGA	EGEEPLIVPEV	DEG_COP1_1	0.2778
p.R566Q	DO220872	MELA	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.2778
p.R566Q	DO219493	SKCM	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.2778
p.R566Q	DO41020	UCEC	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.2778
p.R566Q	DO41903	UCEC	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.2778
p.E563K	TCGA-EE-A20C	SKCM	TCGA	EGEEPLIVPEV	DEG_COP1_1	0.7022
p.E563K	DO222775	MELA	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.7022
p.E563K	DO47665	SKCM	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.7022
p.V561L	TCGA-EE-A3AA	SKCM	TCGA	EGEEPLIVPEV	DEG_COP1_1	0.6765
p.V561L	DO37571	SKCM	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.6765
p.N546K	DO218333	BRCA	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.1111
p.V548F	DO229019	LICA	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.1667
p.C553F	DO229025	LICA	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.3056
p.C545F	DO229006	LICA	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.0833
p.P568T	DO46897	RECA	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.2222
p.P568Q	DO46897	RECA	ICGC	EGEEPLIVPEV	DEG_COP1_1	0.2222
p.A571V	SIDM00839	Colorectal Carcinoma	GDSC	EGEEPLIVPEV	DEG_COP1_1	0.1389
p.A571V	ACH-000950	Colon/Colorectal Cancer	CCLE	EGEEPLIVPEV	DEG_COP1_1	0.1389
p.A571V	LoVo	large_intestine	COSMIC	EGEEPLIVPEV	DEG_COP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EGEEPLIVPEV

Degron related mutations and impact score

Drug responses associated with FBLN2 mutations

All proteins holding degron of EGEEPLIVPEV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98095	Fibulin-2	DEG_COP1_1	554:564	EGEEPLIVPEV	COP1	0.5208	More...