DegronMD - Q00537(CDK17)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R177H	TCGA-B5-A11E	UCEC	TCGA	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.7133
p.R177H	DO41644	UCEC	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.7133
p.R174Q	TCGA-BK-A6W3	UCEC	TCGA	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.25
p.R174Q	DO50076	UCEC	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.25
p.S176F	TCGA-D1-A17Q	UCEC	TCGA	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation blocking phosphorylation signal	0.75
p.S176F	DO41903	UCEC	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation blocking phosphorylation signal	0.75
p.K194E	TCGA-EE-A180	SKCM	TCGA	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation blocking ubiquitination signal	0.5278
p.K194E	DO47537	SKCM	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation blocking ubiquitination signal	0.5278
p.R174L	DO50917	LICA	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.25
p.R178I	DO232761	PBCA	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.8102
p.P167L	SIDM00216	Colorectal Carcinoma	GDSC	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.0556
p.P167L	ACH-000989	Colon/Colorectal Cancer	CCLE	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.0556
p.P167L	SNU-175	large intestine	COSMIC	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.0556
p.S180C	SIDM00241	Breast Carcinoma	GDSC	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.7541
p.S180C	OCUB-M	breast	COSMIC	RRASLSEIG	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.7541

Kaplan plot for CDK17 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDK17

UniProt ID: Q00537

Entrez ID: 5128

Protein name: Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDK17 in