DegronMD

Uniprot ID: Q00537

Source protein: Cyclin-dependent kinase 17

Source gene: CDK17

Class: DEG_APCC_DBOX_1

Location: 177:185

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9541

ASA_SCORE: 79.9

COIL: 0.758

CONS_SCORE: 0.5826

DSS_SCORE: 0.3959

HELIX: 0.2043

FCONS_SCORE: 0.8791

RIG_SCORE: 0.7143

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R177H	TCGA-B5-A11E	UCEC	TCGA	RRASLSEIG	DEG_APCC_DBOX_1	0.7133
p.R177H	DO41644	UCEC	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	0.7133
p.R174Q	TCGA-BK-A6W3	UCEC	TCGA	RRASLSEIG	DEG_APCC_DBOX_1	0.25
p.R174Q	DO50076	UCEC	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	0.25
p.S176F	TCGA-D1-A17Q	UCEC	TCGA	RRASLSEIG	DEG_APCC_DBOX_1	0.75
p.S176F	DO41903	UCEC	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	0.75
p.K194E	TCGA-EE-A180	SKCM	TCGA	RRASLSEIG	DEG_APCC_DBOX_1	0.5278
p.K194E	DO47537	SKCM	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	0.5278
p.R174L	DO50917	LICA	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	0.25
p.R178I	DO232761	PBCA	ICGC	RRASLSEIG	DEG_APCC_DBOX_1	0.8102
p.P167L	SIDM00216	Colorectal Carcinoma	GDSC	RRASLSEIG	DEG_APCC_DBOX_1	0.0556
p.P167L	ACH-000989	Colon/Colorectal Cancer	CCLE	RRASLSEIG	DEG_APCC_DBOX_1	0.0556
p.P167L	SNU-175	large_intestine	COSMIC	RRASLSEIG	DEG_APCC_DBOX_1	0.0556
p.S180C	SIDM00241	Breast Carcinoma	GDSC	RRASLSEIG	DEG_APCC_DBOX_1	0.7541
p.S180C	OCUB-M	breast	COSMIC	RRASLSEIG	DEG_APCC_DBOX_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00537	Cyclin-dependent kinase 17	DEG_APCC_DBOX_1	177:185	RRASLSEIG	APC,CDC20,FZR1	0.9541	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons