DegronMD - Q01082(SPTBN1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D819E	TCGA-DJ-A2PU	THCA	TCGA	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation rewiring degron network	0.3056
p.D819E	DO40429	THCA	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation rewiring degron network	0.3056
p.R830W	TCGA-HU-A4G9	STAD	TCGA	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation rewiring degron network	0.2778
p.R830W	DO228587	MALY	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation rewiring degron network	0.2778
p.R830W	DO47789	STAD	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation rewiring degron network	0.2778
p.R823W	DO222804	COCA	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation altering degron motif	0.7523
p.A835S	DO229025	LICA	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation rewiring degron network	0.1389
p.R830L	DO229470	SKCA	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation rewiring degron network	0.2778
p.T838M	SIDM00324	Neuroblastoma	GDSC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation blocking phosphorylation signal	0.5
p.T838M	ACH-001674	Neuroblastoma	CCLE	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation blocking phosphorylation signal	0.5
p.T838M	TGW	autonomic ganglia	COSMIC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation blocking phosphorylation signal	0.5
p.R821K	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation altering degron motif	0.7237
p.R821K	ACH-000878	Lung Cancer	CCLE	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation altering degron motif	0.7237
p.R821K	HCC-15	lung	COSMIC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation altering degron motif	0.7237
p.Y831H	ACH-000998	Colon/Colorectal Cancer	CCLE	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation blocking phosphorylation signal	0.6944
p.Y831H	CW-2	large intestine	COSMIC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation blocking phosphorylation signal	0.6944
p.P811S	ACH-001970	Metastasis	CCLE	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation rewiring degron network	0.0833
p.Y818H	CW-2	large intestine	COSMIC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation rewiring degron network	0.2778
p.T825M	TGW	autonomic ganglia	COSMIC	VRGRLSGIE	DEG_APCC_DBOX_1	820:828	Mutation altering degron motif	0.7423

Kaplan plot for SPTBN1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPTBN1

UniProt ID: Q01082

Entrez ID: 6711

Protein name: Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SPTBN1 in