DegronMD

Uniprot ID: Q01082

Source protein: Spectrin beta chain, non-erythrocytic 1

Source gene: SPTBN1

Class: DEG_APCC_DBOX_1

Location: 820:828

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7416

ASA_SCORE: 50.3222

COIL: 0.0414

CONS_SCORE: 0.4689

DSS_SCORE: 0.4761

HELIX: 0.9566

FCONS_SCORE: 1.0321

RIG_SCORE: 0.6793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D819E	TCGA-DJ-A2PU	THCA	TCGA	VRGRLSGIE	DEG_APCC_DBOX_1	0.3056
p.D819E	DO40429	THCA	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	0.3056
p.R830W	TCGA-HU-A4G9	STAD	TCGA	VRGRLSGIE	DEG_APCC_DBOX_1	0.2778
p.R830W	DO228587	MALY	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	0.2778
p.R830W	DO47789	STAD	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	0.2778
p.R823W	DO222804	COCA	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	0.7523
p.A835S	DO229025	LICA	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	0.1389
p.R830L	DO229470	SKCA	ICGC	VRGRLSGIE	DEG_APCC_DBOX_1	0.2778
p.T838M	SIDM00324	Neuroblastoma	GDSC	VRGRLSGIE	DEG_APCC_DBOX_1	0.5
p.T838M	ACH-001674	Neuroblastoma	CCLE	VRGRLSGIE	DEG_APCC_DBOX_1	0.5
p.T838M	TGW	autonomic_ganglia	COSMIC	VRGRLSGIE	DEG_APCC_DBOX_1	0.5
p.R821K	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VRGRLSGIE	DEG_APCC_DBOX_1	0.7237
p.R821K	ACH-000878	Lung Cancer	CCLE	VRGRLSGIE	DEG_APCC_DBOX_1	0.7237
p.R821K	HCC-15	lung	COSMIC	VRGRLSGIE	DEG_APCC_DBOX_1	0.7237
p.Y831H	ACH-000998	Colon/Colorectal Cancer	CCLE	VRGRLSGIE	DEG_APCC_DBOX_1	0.6944
p.Y831H	CW-2	large_intestine	COSMIC	VRGRLSGIE	DEG_APCC_DBOX_1	0.6944
p.P811S	ACH-001970	Metastasis	CCLE	VRGRLSGIE	DEG_APCC_DBOX_1	0.0833
p.Y818H	CW-2	large_intestine	COSMIC	VRGRLSGIE	DEG_APCC_DBOX_1	0.2778
p.T825M	TGW	autonomic_ganglia	COSMIC	VRGRLSGIE	DEG_APCC_DBOX_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01082	Spectrin beta chain, non-erythrocytic 1	DEG_APCC_DBOX_1	820:828	VRGRLSGIE	APC,CDC20,FZR1	0.7416	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons