DegronMD - Q01094(E2F1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I306V	TCGA-05-4250	LUAD	TCGA	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.2778
p.I306V	DO24457	LUAD	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.2778
p.G305W	TCGA-53-7626	LUAD	TCGA	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.25
p.G305W	DO23774	LUAD	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.25
p.E321D	TCGA-AP-A0LM	UCEC	TCGA	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.1667
p.E321D	DO43306	UCEC	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.1667
p.P299H	TCGA-B5-A11E	UCEC	TCGA	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.0833
p.P299H	DO41644	UCEC	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.0833
p.G305V	TCGA-FS-A1Z4	SKCM	TCGA	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.25
p.G305V	DO37462	SKCM	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.25
p.P299S	DO227816	COCA	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.0833
p.P308T	DO229041	LICA	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation altering degron motif	0.7031
p.S318A	DO233298	NACA	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.25
p.A324T	SIDM00371	Pancreatic Carcinoma	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.0833
p.A324T	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.0833
p.A324T	SIDM00556	Neuroblastoma	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.0833
p.A324T	KYSE-510	oesophagus	COSMIC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.0833
p.A324T	SUIT-2	pancreas	COSMIC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.0833
p.A324T	KP-N-YN	autonomic ganglia	COSMIC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.0833
p.G309E	SIDM00553	Acute Myeloid Leukemia	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation altering degron motif	0.6087
p.G309E	ACH-002262	Leukemia	CCLE	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation altering degron motif	0.6087
p.G309E	KY821	haematopoietic and lymphoid tissue	COSMIC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation altering degron motif	0.6087
p.G309R	SIDM00013	Melanoma	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation altering degron motif	0.6457
p.G309R	ACH-002387	Skin Cancer	CCLE	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation altering degron motif	0.6457
p.R323K	SIDM00257	Neuroblastoma	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	308:315	Mutation rewiring degron network	0.1111

Kaplan plot for E2F1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

E2F1

UniProt ID: Q01094

Entrez ID: 1869

Protein name: Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for E2F1 in