DegronMD

Uniprot ID: Q01094

Source protein: Transcription factor E2F1

Source gene: E2F1

Class: DEG_SCF_FBW7_2

Location: 308:315

E3 ligase: FBXW7

DEGRON score: 0.9504

ASA_SCORE: 98.5

COIL: 0.9119

CONS_SCORE: 0.4028

DSS_SCORE: 0.7282

HELIX: 0.0404

FCONS_SCORE: 0.9749

RIG_SCORE: 0.616

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I306V	TCGA-05-4250	LUAD	TCGA	PGKTPSQE	DEG_SCF_FBW7_2	0.2778
p.I306V	DO24457	LUAD	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	0.2778
p.G305W	TCGA-53-7626	LUAD	TCGA	PGKTPSQE	DEG_SCF_FBW7_2	0.25
p.G305W	DO23774	LUAD	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	0.25
p.E321D	TCGA-AP-A0LM	UCEC	TCGA	PGKTPSQE	DEG_SCF_FBW7_2	0.1667
p.E321D	DO43306	UCEC	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	0.1667
p.P299H	TCGA-B5-A11E	UCEC	TCGA	PGKTPSQE	DEG_SCF_FBW7_2	0.0833
p.P299H	DO41644	UCEC	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	0.0833
p.G305V	TCGA-FS-A1Z4	SKCM	TCGA	PGKTPSQE	DEG_SCF_FBW7_2	0.25
p.G305V	DO37462	SKCM	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	0.25
p.P299S	DO227816	COCA	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	0.0833
p.P308T	DO229041	LICA	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	0.7031
p.S318A	DO233298	NACA	ICGC	PGKTPSQE	DEG_SCF_FBW7_2	0.25
p.A324T	SIDM00371	Pancreatic Carcinoma	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	0.0833
p.A324T	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	0.0833
p.A324T	SIDM00556	Neuroblastoma	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	0.0833
p.A324T	KYSE-510	oesophagus	COSMIC	PGKTPSQE	DEG_SCF_FBW7_2	0.0833
p.A324T	SUIT-2	pancreas	COSMIC	PGKTPSQE	DEG_SCF_FBW7_2	0.0833
p.A324T	KP-N-YN	autonomic_ganglia	COSMIC	PGKTPSQE	DEG_SCF_FBW7_2	0.0833
p.G309E	SIDM00553	Acute Myeloid Leukemia	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	0.6087
p.G309E	ACH-002262	Leukemia	CCLE	PGKTPSQE	DEG_SCF_FBW7_2	0.6087
p.G309E	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	PGKTPSQE	DEG_SCF_FBW7_2	0.6087
p.G309R	SIDM00013	Melanoma	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	0.6457
p.G309R	ACH-002387	Skin Cancer	CCLE	PGKTPSQE	DEG_SCF_FBW7_2	0.6457
p.R323K	SIDM00257	Neuroblastoma	GDSC	PGKTPSQE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01094	Transcription factor E2F1	DEG_SCF_FBW7_2	308:315	PGKTPSQE	FBXW7	0.9504	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGKTPSQE

Degron related mutations and impact score

Drug responses associated with E2F1 mutations

All proteins holding degron of PGKTPSQE