DegronMD - Q01151(CD83)

CD83

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N191Y	TCGA-AB-2806	LAML	TCGA	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation rewiring degron network	0.1944
p.N191Y	DO21283	LAML	ICGC	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation rewiring degron network	0.1944
p.T202I	DO1203	BRCA	ICGC	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation altering degron motif	0.7078
p.K201N	DO229028	LICA	ICGC	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation altering degron motif	0.5806
p.V205L	DO229031	LICA	ICGC	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation rewiring degron network	0.25
p.T188N	SIDM01175	Other Sarcomas	GDSC	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation rewiring degron network	0.1111
p.T188N	ACH-002309	Sarcoma	CCLE	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation rewiring degron network	0.1111
p.T188N	SW684	soft tissue	COSMIC	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation rewiring degron network	0.1111
p.V197A	SIDM00217	Colorectal Carcinoma	GDSC	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation altering degron motif	0.5825
p.V197A	ACH-000999	Colon/Colorectal Cancer	CCLE	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation altering degron motif	0.5825
p.V197A	SNU-1040	large intestine	COSMIC	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation altering degron motif	0.5825
p.S189Y	ACH-001515	Cervical Cancer	CCLE	LVTPHKT	DEG_SCF_FBW7_1	196:202	Mutation blocking phosphorylation signal	0.5833

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*NOTE: the Kaplan plots were collected from OncoLnc