DegronMD

Uniprot ID: Q01151

Source protein: CD83 antigen

Source gene: CD83

Class: DEG_SCF_FBW7_1

Location: 196:202

E3 ligase: FBXW7

DEGRON score: 0.6066

ASA_SCORE: 85.7571

COIL: 0.779

CONS_SCORE: 0.7119

DSS_SCORE: 0.6084

HELIX: 0.0416

FCONS_SCORE: 0.9845

RIG_SCORE: 0.7549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N191Y	TCGA-AB-2806	LAML	TCGA	LVTPHKT	DEG_SCF_FBW7_1	0.1944
p.N191Y	DO21283	LAML	ICGC	LVTPHKT	DEG_SCF_FBW7_1	0.1944
p.T202I	DO1203	BRCA	ICGC	LVTPHKT	DEG_SCF_FBW7_1	0.7078
p.K201N	DO229028	LICA	ICGC	LVTPHKT	DEG_SCF_FBW7_1	0.5806
p.V205L	DO229031	LICA	ICGC	LVTPHKT	DEG_SCF_FBW7_1	0.25
p.T188N	SIDM01175	Other Sarcomas	GDSC	LVTPHKT	DEG_SCF_FBW7_1	0.1111
p.T188N	ACH-002309	Sarcoma	CCLE	LVTPHKT	DEG_SCF_FBW7_1	0.1111
p.T188N	SW684	soft_tissue	COSMIC	LVTPHKT	DEG_SCF_FBW7_1	0.1111
p.V197A	SIDM00217	Colorectal Carcinoma	GDSC	LVTPHKT	DEG_SCF_FBW7_1	0.5825
p.V197A	ACH-000999	Colon/Colorectal Cancer	CCLE	LVTPHKT	DEG_SCF_FBW7_1	0.5825
p.V197A	SNU-1040	large_intestine	COSMIC	LVTPHKT	DEG_SCF_FBW7_1	0.5825
p.S189Y	ACH-001515	Cervical Cancer	CCLE	LVTPHKT	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01151	CD83 antigen	DEG_SCF_FBW7_1	196:202	LVTPHKT	FBXW7	0.6066	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons