DegronMD - Q01201(RELB)

FUNCTION: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V521M	DO229489	LAML	ICGC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.2222
p.V521M	QGP-1	pancreas	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.2222
p.G527S	DO228955	LICA	ICGC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation altering degron motif	0.6993
p.G530C	DO228974	LICA	ICGC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation altering degron motif	0.6489
p.A520S	DO52124	PAEN	ICGC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.1944
p.L534P	SIDM00419	Ewing's Sarcoma	GDSC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.2778
p.L534P	ACH-000424	Bone Cancer	CCLE	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.2778
p.L534P	TC-71	bone	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.2778
p.P542L	SIDM00654	Small Cell Lung Carcinoma	GDSC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.0556
p.P542L	SIDM00308	Chronic Myelogenous Leukemia	GDSC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.0556
p.P542L	ACH-000074	Leukemia	CCLE	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.0556
p.P542L	ACH-000866	Lung Cancer	CCLE	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.0556
p.P542L	KU812	haematopoietic and lymphoid tissue	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.0556
p.P542L	NCI-H1048	lung	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.0556
p.G526W	SIDM00552	Rhabdomyosarcoma	GDSC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation altering degron motif	0.6714
p.G526W	ACH-000607	Rhabdoid	CCLE	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation altering degron motif	0.6714
p.G526W	KYM-1	soft tissue	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation altering degron motif	0.6714
p.V524M	SIDM00360	Other Solid Cancers	GDSC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.3056
p.V524M	QGP-1	pancreas	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.3056
p.P539L	KU812	haematopoietic and lymphoid tissue	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.1389
p.P539L	NCI-H1048	lung	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.1389
p.L531P	TC-71	bone	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation altering degron motif	0.7582
p.G523W	KYM-1	soft tissue	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	525:532	Mutation rewiring degron network	0.2778

Kaplan plot for RELB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RELB

UniProt ID: Q01201

Entrez ID: 5971

Protein name: Transcription factor RelB (I-Rel)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RELB in