DegronMD

Uniprot ID: Q01201

Source protein: Transcription factor RelB

Source gene: RELB

Class: DEG_SCF_FBW7_2

Location: 525:532

E3 ligase: FBXW7

DEGRON score: 0.9587

ASA_SCORE: 79.8625

COIL: 0.9266

CONS_SCORE: 0.4162

DSS_SCORE: 0.5287

HELIX: 0.0133

FCONS_SCORE: 0.9652

RIG_SCORE: 0.6546

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V521M	DO229489	LAML	ICGC	VGETPGPE	DEG_SCF_FBW7_2	0.2222
p.V521M	QGP-1	pancreas	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	0.2222
p.G527S	DO228955	LICA	ICGC	VGETPGPE	DEG_SCF_FBW7_2	0.6993
p.G530C	DO228974	LICA	ICGC	VGETPGPE	DEG_SCF_FBW7_2	0.6489
p.A520S	DO52124	PAEN	ICGC	VGETPGPE	DEG_SCF_FBW7_2	0.1944
p.L534P	SIDM00419	Ewing's Sarcoma	GDSC	VGETPGPE	DEG_SCF_FBW7_2	0.2778
p.L534P	ACH-000424	Bone Cancer	CCLE	VGETPGPE	DEG_SCF_FBW7_2	0.2778
p.L534P	TC-71	bone	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	0.2778
p.P542L	SIDM00654	Small Cell Lung Carcinoma	GDSC	VGETPGPE	DEG_SCF_FBW7_2	0.0556
p.P542L	SIDM00308	Chronic Myelogenous Leukemia	GDSC	VGETPGPE	DEG_SCF_FBW7_2	0.0556
p.P542L	ACH-000074	Leukemia	CCLE	VGETPGPE	DEG_SCF_FBW7_2	0.0556
p.P542L	ACH-000866	Lung Cancer	CCLE	VGETPGPE	DEG_SCF_FBW7_2	0.0556
p.P542L	KU812	haematopoietic_and_lymphoid_tissue	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	0.0556
p.P542L	NCI-H1048	lung	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	0.0556
p.G526W	SIDM00552	Rhabdomyosarcoma	GDSC	VGETPGPE	DEG_SCF_FBW7_2	0.6714
p.G526W	ACH-000607	Rhabdoid	CCLE	VGETPGPE	DEG_SCF_FBW7_2	0.6714
p.G526W	KYM-1	soft_tissue	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	0.6714
p.V524M	SIDM00360	Other Solid Cancers	GDSC	VGETPGPE	DEG_SCF_FBW7_2	0.3056
p.V524M	QGP-1	pancreas	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	0.3056
p.P539L	KU812	haematopoietic_and_lymphoid_tissue	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	0.1389
p.P539L	NCI-H1048	lung	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	0.1389
p.L531P	TC-71	bone	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	0.7582
p.G523W	KYM-1	soft_tissue	COSMIC	VGETPGPE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01201	Transcription factor RelB	DEG_SCF_FBW7_2	525:532	VGETPGPE	FBXW7	0.9587	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons