DegronMD - Q01432(AMPD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P113L	TCGA-19-1787	GBM	TCGA	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P113L	TCGA-CG-4436	STAD	TCGA	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P113L	TCGA-F7-A50J	HNSC	TCGA	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P113L	DO13522	GBM	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P113L	DO44431	HNSC	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P113L	DO38320	STAD	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P113L	SIDM00296	Small Cell Lung Carcinoma	GDSC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P113L	ACH-002051	Lung Cancer	CCLE	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P113L	LU-134-A	lung	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P109L	TCGA-A2-A0YC	BRCA	TCGA	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P109L	DO1250	BRCA	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P109L	SIDM00673	Breast Carcinoma	GDSC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P109L	HCC70	breast	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582
p.P108S	TCGA-B6-A1KN	BRCA	TCGA	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.6752
p.P108S	DO3656	BRCA	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.6752
p.G107A	TCGA-D1-A177	UCEC	TCGA	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation blocking phosphorylation signal	0.75
p.G107A	DO233791	GACA	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation blocking phosphorylation signal	0.75
p.G107A	DO42528	UCEC	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation blocking phosphorylation signal	0.75
p.G107A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation blocking phosphorylation signal	0.75
p.M115V	TCGA-J2-A4AD	LUAD	TCGA	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.3056
p.M115V	DO23915	LUAD	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.3056
p.P100L	TCGA-QQ-A5V9	SARC	TCGA	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.1111
p.P100L	DO220245	SARC	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.1111
p.P100L	HCC70	breast	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.1111
p.V122I	DO233854	GACA	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.1111
p.W105L	DO229009	LICA	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.25
p.M99I	DO32103	OV	ICGC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.0833
p.D104N	SIDM00545	Melanoma	GDSC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.2222
p.D104N	SIDM00856	Other Solid Cancers	GDSC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.2222
p.D104N	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.2222
p.P120S	SIDM00007	Other Solid Cancers	GDSC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.1667
p.P120S	ACH-001550	Skin Cancer	CCLE	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.1667
p.P120S	MCC13	skin	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.1667
p.P120H	SIDM00363	Acute Myeloid Leukemia	GDSC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.1667
p.P120H	ACH-000770	Leukemia	CCLE	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.1667
p.P120H	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.1667
p.P117H	SIDM01608	Endometrial Carcinoma	GDSC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.25
p.P117H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.25
p.P118H	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.2222
p.P111H	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7694
p.P107L	HCC70	breast	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation blocking phosphorylation signal	0.75
p.P104L	LU-134-A	lung	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.2222
p.P111S	MCC13	skin	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.6752
p.P118S	MCC13	skin	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.2222
p.K112I	IGR-1	skin	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7531
p.A104V	NCI-H510A	lung	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation rewiring degron network	0.2222
p.P111L	LU-134-A	lung	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	108:114	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMPD3

UniProt ID: Q01432

Entrez ID: 272

Protein name: AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AMPD3 in