DegronMD

Uniprot ID: Q01432

Source protein: AMP deaminase 3

Source gene: AMPD3

Class: DEG_SCF_FBW7_1

Location: 108:114

E3 ligase: FBXW7

DEGRON score: 0.9957

ASA_SCORE: 85.2143

COIL: 0.9389

CONS_SCORE: 0.3084

DSS_SCORE: 0.56

HELIX: 0.0174

FCONS_SCORE: 0.9586

RIG_SCORE: 0.6558

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P113L	TCGA-19-1787	GBM	TCGA	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P113L	TCGA-CG-4436	STAD	TCGA	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P113L	TCGA-F7-A50J	HNSC	TCGA	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P113L	DO13522	GBM	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P113L	DO44431	HNSC	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P113L	DO38320	STAD	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P113L	SIDM00296	Small Cell Lung Carcinoma	GDSC	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P113L	ACH-002051	Lung Cancer	CCLE	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P113L	LU-134-A	lung	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P109L	TCGA-A2-A0YC	BRCA	TCGA	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P109L	DO1250	BRCA	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P109L	SIDM00673	Breast Carcinoma	GDSC	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P109L	HCC70	breast	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.7582
p.P108S	TCGA-B6-A1KN	BRCA	TCGA	PTTPVVT	DEG_SCF_FBW7_1	0.6752
p.P108S	DO3656	BRCA	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.6752
p.G107A	TCGA-D1-A177	UCEC	TCGA	PTTPVVT	DEG_SCF_FBW7_1	0.75
p.G107A	DO233791	GACA	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.75
p.G107A	DO42528	UCEC	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.75
p.G107A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PTTPVVT	DEG_SCF_FBW7_1	0.75
p.M115V	TCGA-J2-A4AD	LUAD	TCGA	PTTPVVT	DEG_SCF_FBW7_1	0.3056
p.M115V	DO23915	LUAD	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.3056
p.P100L	TCGA-QQ-A5V9	SARC	TCGA	PTTPVVT	DEG_SCF_FBW7_1	0.1111
p.P100L	DO220245	SARC	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.1111
p.P100L	HCC70	breast	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.1111
p.V122I	DO233854	GACA	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.1111
p.W105L	DO229009	LICA	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.25
p.M99I	DO32103	OV	ICGC	PTTPVVT	DEG_SCF_FBW7_1	0.0833
p.D104N	SIDM00545	Melanoma	GDSC	PTTPVVT	DEG_SCF_FBW7_1	0.2222
p.D104N	SIDM00856	Other Solid Cancers	GDSC	PTTPVVT	DEG_SCF_FBW7_1	0.2222
p.D104N	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTTPVVT	DEG_SCF_FBW7_1	0.2222
p.P120S	SIDM00007	Other Solid Cancers	GDSC	PTTPVVT	DEG_SCF_FBW7_1	0.1667
p.P120S	ACH-001550	Skin Cancer	CCLE	PTTPVVT	DEG_SCF_FBW7_1	0.1667
p.P120S	MCC13	skin	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.1667
p.P120H	SIDM00363	Acute Myeloid Leukemia	GDSC	PTTPVVT	DEG_SCF_FBW7_1	0.1667
p.P120H	ACH-000770	Leukemia	CCLE	PTTPVVT	DEG_SCF_FBW7_1	0.1667
p.P120H	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.1667
p.P117H	SIDM01608	Endometrial Carcinoma	GDSC	PTTPVVT	DEG_SCF_FBW7_1	0.25
p.P117H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTTPVVT	DEG_SCF_FBW7_1	0.25
p.P118H	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.2222
p.P111H	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.7694
p.P107L	HCC70	breast	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.75
p.P104L	LU-134-A	lung	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.2222
p.P111S	MCC13	skin	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.6752
p.P118S	MCC13	skin	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.2222
p.K112I	IGR-1	skin	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.7531
p.A104V	NCI-H510A	lung	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.2222
p.P111L	LU-134-A	lung	COSMIC	PTTPVVT	DEG_SCF_FBW7_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTPVVT

Degron related mutations and impact score

Drug responses associated with AMPD3 mutations

All proteins holding degron of PTTPVVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01432	AMP deaminase 3	DEG_SCF_FBW7_1	108:114	PTTPVVT	FBXW7	0.9957	More...